多发性硬化症患者的基础皮质醇水平及其与临床症状的关系：一项系统综述
Basal cortisol levels and the relationship with clinical symptoms in multiple sclerosis: a systematic review.
作者信息
Pereira Gabriela Magalhães, Soares Nayron Medeiros, Souza Andreo Rysdyk de, Becker Jefferson, Finkelsztejn Alessandro, Almeida Rosa Maria Martins de
机构信息
Universidade Federal do Rio Grande do Sul, Instituto de Ciências Básicas da Saúde, Laboratório de Psicologia Experimental, Neurociências e Comportamento, Porto Alegre RS, Brasil.
Universidade Federal do Rio Grande do Sul, Faculdade de Medicina, Laboratório de Psicologia Experimental, Neurociências e Comportamento, Porto Alegre RS, Brasil.
出版信息
Arq Neuropsiquiatr. 2018 Sep;76(9):622-634. doi: 10.1590/0004-282X20180091.
Multiple sclerosis (MS) is a demyelinating, progressive and neurodegenerative disease. A disturbance on the hypothalamic-pituitary-adrenal axis can be observed in patients with MS, showing altered cortisol levels. We aimed to identify basal cortisol levels and verify the relationship with clinical symptoms in patients with MS. A systematic search was conducted in the databases: Pubmed, Web of Science and SCOPUS. Both higher and lower cortisol levels were associated with MS. Higher cortisol levels were associated with depression and anxiety, while lower levels were associated with depression, fatigue and urinary dysfunction. Higher cortisol levels may be associated with the progression and severity of MS.
多发性硬化症（MS）是一种脱髓鞘、进行性的神经退行性疾病。在MS患者中可观察到下丘脑-垂体-肾上腺轴的紊乱，表现为皮质醇水平改变。我们旨在确定MS患者的基础皮质醇水平，并验证其与临床症状的关系。在以下数据库中进行了系统检索：PubMed、科学网和Scopus。皮质醇水平的升高和降低均与MS相关。较高的皮质醇水平与抑郁和焦虑相关，而较低水平与抑郁、疲劳及排尿功能障碍相关。较高的皮质醇水平可能与MS的进展和严重程度相关。
Zotero 插件