Freitas Maria Camila Pruper de, Fernandez Diana Gabriela Estevez, Cohen Danielle, Figueiredo-Neto Antônio Martins, Maranhão Raul Cavalcante, Damasceno Nágila Raquel Teixeira
Departamento de Nutricao, Faculdade de Saude Publica da Universidade de Sao Paulo, Sao Paulo, SP, BR.
Programa de Interunidades em Nutricao Humana Aplicada, Faculdade de Ciencias Farmaceuticas da Universidade de Sao Paulo, Sao Paulo, SP, BR.
Clinics (Sao Paulo). 2018 Oct 18;73:e189. doi: 10.6061/clinics/2018/e189.
To evaluate biomarkers associated with early cardiometabolic risk in obese adolescents.
This cross-sectional study included 137 adolescents of both sexes aged 10 to 19 years divided into a normal weight group (NW) (n=69) and an obese group (OB) (n=68).
As expected, obesity showed positive associations with homeostatic model assessment for insulin resistance (HOMA-IR), triacylglycerol, insulin, plasma levels of non-esterified fatty acids, and cholesterol ester transfer protein activity and negative associations with plasma antioxidant levels. Plasma oxidized low-density lipoprotein (oxLDL) and electronegative low-density lipoprotein [LDL(-)] levels were significantly higher in the OB group. Higher tertiles of oxLDL were associated with increased values of body mass index; waist circumference; fatty mass percentage (%FM); and the atherogenic lipids non-high-density-lipoprotein cholesterol (non-HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B and triacylglycerol. Higher tertiles of LDL(-) were robustly associated with body mass index and waist circumference. Logistic regression models (odds ratios) confirmed that increased values of lipids and apolipoprotein B were associated with increased risk of oxLDL. For LDL(-), these associations were not significant, suggesting that another mechanism is involved in generating this particle in obese adolescents.
Obese adolescents showed increased plasma LDL(-) and oxLDL, and obese girls had more LDL(-) than obese boys. Therefore, oxLDL is strongly and independently associated with classical cardiovascular risk factors, while increased levels of LDL(-) were influenced by body mass index, waist circumference and demographic parameters in obese adolescents.
评估与肥胖青少年早期心脏代谢风险相关的生物标志物。
这项横断面研究纳入了137名年龄在10至19岁的青少年，分为正常体重组（NW）（n = 69）和肥胖组（OB）（n = 68）。
不出所料，肥胖与胰岛素抵抗的稳态模型评估（HOMA-IR）、三酰甘油、胰岛素、非酯化脂肪酸血浆水平以及胆固醇酯转运蛋白活性呈正相关，与血浆抗氧化剂水平呈负相关。OB组的血浆氧化低密度脂蛋白（oxLDL）和带负电荷的低密度脂蛋白[LDL(-)]水平显著更高。oxLDL较高的三分位数与体重指数、腰围、脂肪量百分比（%FM）以及致动脉粥样硬化脂质非高密度脂蛋白胆固醇（非HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白B和三酰甘油的值升高相关。LDL(-)较高的三分位数与体重指数和腰围密切相关。逻辑回归模型（比值比）证实，脂质和载脂蛋白B值的增加与oxLDL风险增加相关。对于LDL(-)，这些关联不显著，表明在肥胖青少年中产生这种颗粒涉及另一种机制。
肥胖青少年的血浆LDL(-)和oxLDL升高，肥胖女孩的LDL(-)比肥胖男孩更多。因此，oxLDL与经典心血管危险因素密切且独立相关，而肥胖青少年中LDL(-)水平的升高受体重指数、腰围和人口统计学参数的影响。
