HSD17B13 在肝脏生理学和病理生理学中的作用。
Role of HSD17B13 in the liver physiology and pathophysiology.
机构信息
Shenzhen University Medical Center, Shenzhen University Health Science Center, Shenzhen, China; Department of Pathology, Shenzhen University Health Science Center, Shenzhen, China.
Shenzhen University Medical Center, Shenzhen University Health Science Center, Shenzhen, China.
出版信息
Mol Cell Endocrinol. 2019 Jun 1;489:119-125. doi: 10.1016/j.mce.2018.10.014. Epub 2018 Oct 24.
17β-Hydroxysteroid dehydrogenases (HSD17Bs) comprise a large family of 15 members that are mainly involved in sex hormone metabolism. Some HSD17Bs enzymes also play key roles in cholesterol and fatty acid metabolism. Recent study showed that hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), an enzyme with unknown biological function, is a novel liver-specific lipid droplet (LD)-associated protein in mouse and humans. HSD17B13 expression is markedly upregulated in patients and mice with non-alcoholic fatty liver disease (NAFLD). Hepatic overexpression of HSD17B13 promotes lipid accumulation in the liver. In this review, we summarize recent progress regarding the role of HSD17B13 in the regulation of hepatic lipid homeostasis and discuss genetic, genomic and proteomic evidence supporting the pathogenic role of HSD17B13 in NAFLD. We also emphasize its potential as a biomarker of advanced liver disease, such as non-alcoholic steatohepatitis (NASH) and liver cancer.
17β-羟甾类脱氢酶（HSD17B）家族由 15 个成员组成，主要参与性激素代谢。一些 HSD17B 酶也在胆固醇和脂肪酸代谢中发挥关键作用。最近的研究表明，羟甾类 17β-脱氢酶 13（HSD17B13），一种具有未知生物学功能的酶，是小鼠和人类肝脏中新型的特异性脂滴（LD）相关蛋白。在非酒精性脂肪性肝病（NAFLD）患者和小鼠中，HSD17B13 的表达明显上调。肝脏中 HSD17B13 的过表达促进了肝脏中的脂质积累。在这篇综述中，我们总结了 HSD17B13 在调节肝脏脂质稳态中的作用的最新进展，并讨论了支持 HSD17B13 在 NAFLD 中发挥致病作用的遗传、基因组和蛋白质组证据。我们还强调了它作为先进肝脏疾病（如非酒精性脂肪性肝炎（NASH）和肝癌）的生物标志物的潜力。
Zotero 插件