Panduro Arturo, Roman Sonia, Mariscal-Martinez Irene M, Jose-Abrego Alexis, Gonzalez-Aldaco Karina, Ojeda-Granados Claudia, Ramos-Lopez Omar, Torres-Reyes Luis A
Department of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara, Fray Antonio Alcalde, Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco, Mexico.
Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, Catania, Italy.
Front Nutr. 2024 May 9;11:1379364. doi: 10.3389/fnut.2024.1379364. eCollection 2024.
Chronic liver disease is a global health issue. Patients with chronic liver disease require a fresh approach that focuses on the genetic and environmental factors that contribute to disease initiation and progression. Emerging knowledge in the fields of Genomic Medicine and Genomic Nutrition demonstrates differences between countries in terms of genetics and lifestyle risk factors such as diet, physical activity, and mental health in chronic liver disease, which serves as the foundation for the implementation of Personalized Medicine and Nutrition (PerMed-Nut) strategies. Most of the world's populations have descended from various ethnic groupings. Mexico's population has a tripartite ancestral background, consisting of Amerindian, European, and African lineages, which is common across Latin America's regional countries. The purpose of this review is to discuss the genetic and environmental components that could be incorporated into a PerMed-Nut model for metabolic-associated liver disease, viral hepatitis B and C, and hepatocellular carcinoma in Mexico. Additionally, the implementation of the PerMed-Nut approach will require updated medicine and nutrition education curricula. Training and equipping future health professionals and researchers with new clinical and investigative abilities focused on preventing liver illnesses in the field of genomic hepatology globally is a vision that clinicians and nutritionists should be concerned about.
慢性肝病是一个全球性的健康问题。慢性肝病患者需要一种全新的方法,该方法应聚焦于导致疾病发生和进展的遗传及环境因素。基因组医学和基因组营养学领域的新知识表明,在慢性肝病方面,不同国家在遗传学以及饮食、体育活动和心理健康等生活方式风险因素方面存在差异,这为实施个性化医学和营养(PerMed-Nut)策略奠定了基础。世界上大多数人口都源自不同的族群。墨西哥人口具有三方祖先背景,包括美洲印第安人、欧洲人和非洲人血统,这在拉丁美洲各地区国家很常见。本综述的目的是讨论可纳入墨西哥代谢相关肝病、乙型和丙型病毒性肝炎以及肝细胞癌的PerMed-Nut模型中的遗传和环境因素。此外,实施PerMed-Nut方法将需要更新医学和营养教育课程。临床医生和营养学家应关注这样一个愿景,即培养未来的健康专业人员和研究人员具备专注于在全球基因组肝脏病学领域预防肝脏疾病的新临床和研究能力。