Rague James T, Lee Richard S
Boston Medical Center, Department of Urology, Boston MA.
Harvard Medical School, Department of Surgery and Boston Children's Hospital, Department of Urology, Boston, MA.
Urology. 2019 Feb;124:257-259. doi: 10.1016/j.urology.2018.10.028. Epub 2018 Oct 24.
High-grade urothelial carcinoma of the bladder is rare in the pediatric population with no established guidelines for management. We treated a single female patient, 10 years of age, who was found to have high-grade, nonmuscle invasive urothelial carcinoma endoscopically and with intravesical bacille calmette guerin (BCG). Given the child's age, no local adult institution could provide BCG therapy. Utilizing the experience of the local adult institutions, we developed a comprehensive protocol for first-time delivery of BCG at a free-standing children's hospital. The patient has undergone successful induction and maintenance BCG for 7 cycles without disease recurrence and minimal side effects.
高级别膀胱尿路上皮癌在儿童群体中较为罕见，目前尚无既定的管理指南。我们治疗了一名10岁的女性患者，经内镜检查发现其患有高级别非肌层浸润性膀胱尿路上皮癌，并接受了膀胱内卡介苗（BCG）治疗。鉴于患儿的年龄，当地没有成人机构能够提供卡介苗治疗。我们借鉴当地成人机构的经验，制定了一套在一家独立儿童医院首次使用卡介苗的综合方案。该患者已成功接受了7个周期的卡介苗诱导和维持治疗，无疾病复发，且副作用极小。
