Pharmacology and Experimental Therapeutics Unit, School of Pharmacy, Institute for Drug Research, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Pharmacology and Experimental Therapeutics Unit, School of Pharmacy, Institute for Drug Research, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Clin Immunol. 2019 Jul;204:64-68. doi: 10.1016/j.clim.2018.10.014. Epub 2018 Oct 24.
The signaling lymphocytic activation molecule (SLAM) family of receptors (SLAMF) is a group of receptors belonging to the CD2 family. It is composed of several members expressed on many hematopoietic cells. Most of the receptors interact in a homophilic fashion with neighboring cells. Their distribution and binding properties, together with their ability to function as both activating and inhibitory receptors, put them as key players in the immune system regulation. Several SLAM family receptors have been extensively investigated. This review mainly focuses on CD244 (2B4 or SLAMF4,) and CD48, particularly as expressed by the key cells of allergy, mast cells and eosinophils.
信号淋巴细胞激活分子（SLAM）家族受体（SLAMF）是 CD2 家族的一组受体。它由许多造血细胞上表达的几个成员组成。大多数受体以同种型相互作用与相邻细胞相互作用。它们的分布和结合特性，以及它们作为激活和抑制受体的功能能力，使它们成为免疫系统调节的关键因素。已经对几种 SLAM 家族受体进行了广泛研究。本综述主要集中在 CD244（2B4 或 SLAMF4）和 CD48 上，特别是在过敏的关键细胞——肥大细胞和嗜酸性粒细胞上的表达。
