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深入了解 CD244（SLAMF4）在免疫调节和相关疾病中的作用的进展。

Advances in Understanding the Roles of CD244 (SLAMF4) in Immune Regulation and Associated Diseases.

机构信息

Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China.

出版信息

Front Immunol. 2021 Mar 24;12:648182. doi: 10.3389/fimmu.2021.648182. eCollection 2021.

DOI:10.3389/fimmu.2021.648182
PMID:33841431
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8024546/
Abstract

Proteins in the signaling lymphocytic activating molecule (SLAM) family play crucial roles in regulating the immune system. CD244 (SLAMF4) is a protein in this family, and is also a member of the CD2 subset of the immunoglobulin (Ig) superfamily. CD244 is a cell surface protein expressed by NK cells, T cells, monocytes, eosinophils, myeloid-derived suppressor cells, and dendritic cells. CD244 binds to the ligand CD48 on adjacent cells and transmits stimulatory or inhibitory signals that regulate immune function. In-depth studies reported that CD244 functions in many immune-related diseases, such as autoimmune diseases, infectious diseases, and cancers, and its action is essential for the onset and progression of these diseases. The discovery of these essential roles of CD244 suggests it has potential as a prognostic indicator or therapeutic target. This review describes the molecular structure and function of CD244 and its roles in various immune cells and immune-related diseases.

摘要

信号淋巴细胞激活分子（SLAM）家族中的蛋白质在调节免疫系统中起着至关重要的作用。CD244（SLAMF4）是该家族中的一种蛋白质，也是免疫球蛋白（Ig）超家族 CD2 亚组的成员。CD244 是一种表达于 NK 细胞、T 细胞、单核细胞、嗜酸性粒细胞、髓系来源的抑制细胞和树突状细胞表面的蛋白。CD244 与相邻细胞上的配体 CD48 结合，传递调节免疫功能的刺激或抑制信号。深入的研究报道，CD244 在许多与免疫相关的疾病中发挥作用，如自身免疫性疾病、传染病和癌症，其作用对于这些疾病的发生和进展是必不可少的。CD244 的这些重要作用的发现表明它有作为预后指标或治疗靶标的潜力。本文综述了 CD244 的分子结构和功能及其在各种免疫细胞和免疫相关疾病中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c8/8024546/51821951b898/fimmu-12-648182-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c8/8024546/c2ab1e0439ae/fimmu-12-648182-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c8/8024546/51821951b898/fimmu-12-648182-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c8/8024546/c2ab1e0439ae/fimmu-12-648182-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c8/8024546/51821951b898/fimmu-12-648182-g0002.jpg

相似文献

[1]
Advances in Understanding the Roles of CD244 (SLAMF4) in Immune Regulation and Associated Diseases.

Front Immunol. 2021

[2]
Chicken SLAMF4 (CD244, 2B4), a receptor expressed on thrombocytes, monocytes, NK cells, and subsets of αβ-, γδ- T cells and B cells binds to SLAMF2.

Dev Comp Immunol. 2014-2

[3]
2B4 (CD244, SLAMF4) and CS1 (CD319, SLAMF7) in systemic lupus erythematosus and cancer.

Clin Immunol. 2018-10-19

[4]
2B4 and CD48: A powerful couple of the immune system.

Clin Immunol. 2018-10-24

[5]
The Emerging Role of CD244 Signaling in Immune Cells of the Tumor Microenvironment.

Front Immunol. 2018-11-28

[6]
Selective Loss of Signaling Lymphocytic Activation Molecule Family Member 4-Positive CD8+ T Cells Contributes to the Decreased Cytotoxic Cell Activity in Systemic Lupus Erythematosus.

Arthritis Rheumatol. 2016-1

[7]
CD244 is expressed on dendritic cells and regulates their functions.

Immunol Cell Biol. 2015-7

[8]
Simultaneous TCR and CD244 signals induce dynamic downmodulation of CD244 on human antiviral T cells.

J Immunol. 2013-8-2

[9]
2B4 (CD244) and CS1: novel members of the CD2 subset of the immunoglobulin superfamily molecules expressed on natural killer cells and other leukocytes.

Immunol Rev. 2001-6

[10]
Mutational analysis of the human 2B4 (CD244)/CD48 interaction: Lys68 and Glu70 in the V domain of 2B4 are critical for CD48 binding and functional activation of NK cells.

J Immunol. 2005-7-15

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[9]
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[10]
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本文引用的文献

[1]
Roles of NK Cell Receptors 2B4 (CD244), CS1 (CD319), and LLT1 (CLEC2D) in Cancer.

Cancers (Basel). 2020-7-1

[2]
NK Cell-Based Immunotherapies in Cancer.

Immune Netw. 2020-3-9

[3]
CD244 represents a new therapeutic target in head and neck squamous cell carcinoma.

J Immunother Cancer. 2020-3

[4]
[Study progress of role of co-suppressor molecules in sepsis immune dysfunction].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2020-1

[5]
The epidemiology of established rheumatoid arthritis.

Best Pract Res Clin Rheumatol. 2020-1-25

[6]
An update on potentials and promises of T cell co-signaling molecules in transplantation.

J Cell Physiol. 2020-5

[7]
TOX is a critical regulator of tumour-specific T cell differentiation.

Nature. 2019-6-17

[8]
2B4 costimulatory domain enhancing cytotoxic ability of anti-CD5 chimeric antigen receptor engineered natural killer cells against T cell malignancies.

J Hematol Oncol. 2019-5-16

[9]
Increased attrition of memory T cells during sepsis requires 2B4.

JCI Insight. 2019-5-2

[10]
Natural Killer Cells and Current Applications of Chimeric Antigen Receptor-Modified NK-92 Cells in Tumor Immunotherapy.

Int J Mol Sci. 2019-1-14

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