Blimp-1 在自身反应性 CD4 T 细胞在自身免疫性脑脊髓炎的初始和效应阶段中的不同作用。
Distinct roles for Blimp-1 in autoreactive CD4 T cells during priming and effector phase of autoimmune encephalomyelitis.
机构信息
Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Neuroscience Program, College of Arts and Sciences, The Ohio State University, Columbus, OH 43210, USA.
出版信息
J Neuroimmunol. 2018 Dec 15;325:20-28. doi: 10.1016/j.jneuroim.2018.10.007. Epub 2018 Oct 15.
Abstract
B lymphocyte-induced maturation protein (Blimp-1) is a transcription factor that regulates effector/memory B cells and CD8 T cells. Here we show that Blimp-1 is expressed in both Th1 and Th17 cells in vitro and highly expressed in effector/memory myelin-specific CD4 T cells in experimental autoimmune encephalomyelitis (EAE) mice. The immunized Blimp-1 conditional knockout mice have a significantly delayed disease onset but enhanced disease severity during the effector phase compared to their wild-type littermates, suggesting that Blimp-1 is a unique transcription factor with distinct roles in the regulation of myelin-specific CD4 T cells during priming and effector phase of EAE.
摘要
B 淋巴细胞诱导成熟蛋白 (Blimp-1) 是一种转录因子，可调节效应器/记忆 B 细胞和 CD8 T 细胞。在这里，我们表明 Blimp-1 在体外的 Th1 和 Th17 细胞中表达，并在实验性自身免疫性脑脊髓炎 (EAE) 小鼠中的效应器/记忆髓鞘特异性 CD4 T 细胞中高度表达。与野生型同窝仔相比，免疫 Blimp-1 条件性敲除小鼠的疾病发作明显延迟，但在效应期疾病严重程度增强，表明 Blimp-1 是一种独特的转录因子，在 EAE 的启动和效应期调节髓鞘特异性 CD4 T 细胞中具有不同的作用。
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