Department of Neurology, Columbia University Medical Center, Milstein Hospital, 177 Fort Washington Avenue, 8GS-300, New York, NY 10032, USA.
Division of Critical Care and Hospitalist Neurology, Department of Neurology, Columbia University Medical Center, Milstein Hospital, 177 Fort Washington Avenue, 8GS-300, New York, NY 10032, USA.
Neurol Clin. 2018 Nov;36(4):767-787. doi: 10.1016/j.ncl.2018.06.003.
Zika virus (ZIKV) is an arthropod-borne virus that belongs to the Flaviviridae family. Although most cases are mild or go undetected, rare severe neurologic effects, including congenital ZIKV syndrome (CZS) and Guillain-Barré syndrome, have been identified. The serious neurologic complications associated with ZIKV prompted the declaration of the public health emergency of international concern by the World Health Organization. Overall, transmission occurred throughout South and Central America as well as the Caribbean, affecting 48 countries and territories from March 2015 to March 2017. Long-term management of CZS requires a comprehensive combination of supportive services throughout early development.
Zika 病毒（ZIKV）是一种虫媒病毒，属于黄病毒科。尽管大多数病例为轻症或未被发现，但已确定存在罕见的严重神经影响，包括先天性 Zika 病毒综合征（CZS）和格林-巴利综合征。与 Zika 病毒相关的严重神经并发症促使世界卫生组织宣布该病毒构成国际关注的突发公共卫生事件。总体而言，该病毒于 2015 年 3 月至 2017 年 3 月在南美洲和中美洲以及加勒比地区传播，影响了 48 个国家和地区。CZS 的长期管理需要在早期发育过程中全面结合支持性服务。
