Amsterdam UMC, University of Amsterdam, Neurology, Amsterdam Neuroscience, Meibergdreef 9, Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Amsterdam UMC, University of Amsterdam, Neurology, Amsterdam Neuroscience, Meibergdreef 9, Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Neurol Clin. 2018 Nov;36(4):809-820. doi: 10.1016/j.ncl.2018.06.007. Epub 2018 Sep 20.
Community-acquired bacterial meningitis remains a disease with high impact. The epidemiology of this disease changed substantiality to large-scale introduction of conjugated vaccines. Streptococcus pneumoniae and Neisseria meningitidis are the main causative pathogens outside the neonatal age. Clinical presentation of patients with bacterial meningitis varies depending on age and underlying condition. A delay in diagnosis and antimicrobial therapy has been associated with increased risk of adverse clinical outcome. Empirical antibiotic treatment should be based on common bacterial species that cause the disease according to the patient's age group or clinical setting and on local antibiotic susceptibility patterns of the predominant pathogens.
社区获得性细菌性脑膜炎仍然是一种具有高影响力的疾病。由于大规模引入结合疫苗，该疾病的流行病学发生了重大变化。在新生儿期以外，肺炎链球菌和脑膜炎奈瑟菌是主要的病原体。细菌性脑膜炎患者的临床表现因年龄和基础疾病而异。诊断和抗菌治疗的延迟与不良临床结局的风险增加有关。经验性抗生素治疗应根据患者的年龄组或临床环境以及主要病原体的局部抗生素敏感性模式，基于常见的引起该疾病的细菌种类进行。
