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AAV Immunogenicity: New Answers Create New Questions.

作者信息

Shirley Jamie L, Herzog Roland W

机构信息

Department of Pediatrics, University of Florida, Gainesville, FL, USA.

Department of Pediatrics, University of Florida, Gainesville, FL, USA; Department of Pediatrics, Indiana University, Indianapolis, IN, USA; IUPUI-Wells Center for Pediatric Research, Indiana University, Indianapolis, IN, USA.

出版信息

Mol Ther. 2018 Nov 7;26(11):2538-2539. doi: 10.1016/j.ymthe.2018.10.004. Epub 2018 Oct 23.

DOI:10.1016/j.ymthe.2018.10.004
PMID:30366819
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6225012/
Abstract
摘要

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本文引用的文献

1
Exposure to wild-type AAV drives distinct capsid immunity profiles in humans.暴露于野生型 AAV 会在人体内引起不同的衣壳免疫特征。
J Clin Invest. 2018 Dec 3;128(12):5267-5279. doi: 10.1172/JCI122372. Epub 2018 Oct 22.
2
Double-stranded RNA innate immune response activation from long-term adeno-associated virus vector transduction.双链 RNA 先天免疫反应激活来自长期腺相关病毒载体转导。
JCI Insight. 2018 Jun 21;3(12). doi: 10.1172/jci.insight.120474.
3
Plasmacytoid and conventional dendritic cells cooperate in crosspriming AAV capsid-specific CD8 T cells.浆细胞样树突状细胞和传统树突状细胞在交叉启动AAV衣壳特异性CD8 T细胞过程中相互协作。
Blood. 2017 Jun 15;129(24):3184-3195. doi: 10.1182/blood-2016-11-751040. Epub 2017 May 3.
4
The Balance between CD8 T Cell-Mediated Clearance of AAV-Encoded Antigen in the Liver and Tolerance Is Dependent on the Vector Dose.肝脏中CD8 T细胞介导的腺相关病毒编码抗原清除与耐受之间的平衡取决于载体剂量。
Mol Ther. 2017 Apr 5;25(4):880-891. doi: 10.1016/j.ymthe.2017.02.014. Epub 2017 Mar 9.