Lab for Clinical and Integrative Neuroscience, School of Behavioral and Brain Science, University of Texas at Dallas, 800 W Campbell Rd, Richardson, TX, 75080, USA.
Department of Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Brain Struct Funct. 2019 Jan;224(1):435-452. doi: 10.1007/s00429-018-1781-3. Epub 2018 Oct 26.
The posteromedial cortex (PMC)-comprising posterior cingulate cortex (PCC), retrosplenial cortex (RSC), and the precuneus (PrC)-is perhaps best known for its involvement in the default mode network. There is no consensus regarding the specific functions of PMC, however, and its component regions each exhibit distinct, but partially overlapping functional profiles. To date, there has been minimal effort to disentangle the functions of these regions. In the present study, we use Neurosynth ( http://neurosynth.org ) to conduct an unbiased meta-analysis of the PMC based on fMRI coactivation and semantic information extracted from 11,406 studies. Our analyses revealed six PMC clusters with distinct functional profiles: superior and inferior dorsal PCC, anterior and posterior PrC, ventral PCC, and RSC. We discuss these findings in the context of the existing literature and suggest several fruitful avenues for continued research.
后扣带皮层（PMC）包括后扣带皮层（PCC）、后扣带皮层（RSC）和楔前叶（PrC），它可能是最著名的默认模式网络的参与。然而，对于 PMC 的具体功能还没有共识，其组成区域各具有独特的但部分重叠的功能特征。迄今为止，很少有人努力厘清这些区域的功能。在本研究中，我们使用 Neurosynth（http://neurosynth.org）基于从 11406 项研究中提取的 fMRI 共激活和语义信息，对 PMC 进行了无偏的元分析。我们的分析揭示了具有不同功能特征的六个 PMC 聚类：上、下背 PCC、前、后 PrC、腹 PCC 和 RSC。我们在现有文献的背景下讨论了这些发现，并提出了一些有前途的继续研究的途径。
