Fishman R H, Feigenbaum J J, Iser-Strenger C, Yanai J
Int J Neurosci. 1987 Feb;32(3-4):845-52. doi: 10.3109/00207458709043339.
Treatment with DES one hour prior to pentobarbital injection resulted in diminution of the narcotic sleep and hypothermia usually found after pentobarbital (50 mg/kg 1) injection in male mice. The effect was biphasic: significantly countered relative to saline pretreated controls at low (.001-.10 mg/kg 1) and at high (10-50 mg/kg -1) DES doses only. Giving DES alone did not change core body temperature compared to saline injected controls, at either 25 degrees C or at 33 degrees C. At 33 degrees C, neither PeB narcosis nor body temperature loss was significantly inhibited by DES. Possible cytoplasmic, nonsex differentiated bases for these estrogen effects on barbiturate action in the brain is discussed.
在给雄性小鼠注射戊巴比妥前一小时用己烯雌酚进行处理，可使通常在注射戊巴比妥（50毫克/千克）后出现的麻醉性睡眠和体温过低现象有所减轻。这种作用呈双相性：仅在低剂量（0.001 - 0.10毫克/千克）和高剂量（10 - 50毫克/千克）己烯雌酚时，相对于用生理盐水预处理的对照组有显著的对抗作用。与注射生理盐水的对照组相比，单独给予己烯雌酚在25摄氏度或33摄氏度时均未改变核心体温。在33摄氏度时，己烯雌酚对戊巴比妥麻醉和体温降低均无显著抑制作用。文中讨论了这些雌激素对大脑中巴比妥类药物作用的可能的细胞质、非性别分化基础。
