Chaabane Amel, Romdhane Haifa Ben, Brahim Hajer Ben, Fredj Nadia Ben, Chadli Zohra, Boughattas Naceur A, Chakroun Mohamed, Aouam Karim
Department of Pharmacology, University of Medicine, Avenue Avicenne 5019 Monastir, Tunisia.
Department of Infectious Diseases, Hospital of Monastir, Monastir, Tunisia.
Acta Parasitol. 2018 Dec 19;63(4):845-847. doi: 10.1515/ap-2018-0104.
We report a case of a 64-year-old woman treated with meglumine antimoniate (Glucantime®). On day 20, she developed fever, a pruriginous skin rash and myalgia. The blood tests showed eosinophilia and hepatic cytolysis. The clinico-biological picture improved gradually and the symptoms disappeared 4 weeks after the drug withdrawal. Six weeks later, intradermal tests to Glucantime® were performed and were positive at 48 hour-reading. This clinical picture suggests DRESS induced by meglumine antimoniate. To the best of our knowledge, only one case of meglumine antimoniate-induced DRESS has been reported in the literature and we are the first to report a case confirmed by skin tests.
我们报告一例64岁女性接受葡甲胺锑酸盐（葡糖酸锑钠®）治疗的病例。在第20天时，她出现发热、瘙痒性皮疹和肌痛。血液检查显示嗜酸性粒细胞增多和肝细胞溶解。临床生物学表现逐渐改善，停药4周后症状消失。六周后，对葡糖酸锑钠®进行了皮内试验，48小时读数时呈阳性。这种临床表现提示为葡甲胺锑酸盐诱发的药物超敏反应伴嗜酸性粒细胞增多和系统症状（DRESS）。据我们所知，文献中仅报道过一例葡甲胺锑酸盐诱发的DRESS，而我们是首例通过皮肤试验确诊的病例报告。
