Dermatology Program, El Bosque University, Bogotá, Colombia.
Internal Medicine Department, University Hospital of the Samaritan ESE, Bogotá, Colombia.
Int J Dermatol. 2018 Nov;57(11):1304-1313. doi: 10.1111/ijd.14126. Epub 2018 Aug 29.
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe drug-induced reaction associated with eosinophilia and systemic manifestations. Anticonvulsants, sulfonamides, and antivirals are the most related and described drugs in DRESS syndrome.
We present a case of severe multiple organ dysfunction syndrome (MODS) with the risk of death associated with DRESS syndrome due to antileishmanial pentavalent antimonial drug and its simultaneous toxicity. Consequently, a comprehensive review of the main clinical problems and comparative discussion of both clinical conditions was made.
The overlap of DRESS syndrome and antileishmanial pentavalent antimonial drug toxicity can be life-threatening. Both conditions represent a true clinical, diagnostic, and therapeutic challenge. We exposed specific clinical and laboratory results with rare occurrence.
Any physician and dermatologists should keep in mind the broad spectrum of clinical manifestations and laboratory findings associated with the use of pentavalent antimonial drugs. The clinical suspicion, an early diagnosis, and aggressive treatment are essential to prevent complications and death.
药物反应伴嗜酸性粒细胞增多和全身性症状（DRESS）综合征是一种严重的药物引起的反应，与嗜酸性粒细胞增多和全身表现有关。抗惊厥药、磺胺类药物和抗病毒药物是 DRESS 综合征中最相关和描述最多的药物。
我们报告了一例由于抗利什曼病五价锑药物及其同时毒性引起的严重多器官功能障碍综合征（MODS）和死亡风险的 DRESS 综合征病例。因此，对主要临床问题进行了全面回顾，并对两种临床情况进行了比较讨论。
DRESS 综合征和抗利什曼病五价锑药物毒性的重叠可能危及生命。这两种情况都代表着真正的临床、诊断和治疗挑战。我们展示了具有罕见发生的具体临床和实验室结果。
任何医生和皮肤科医生都应该牢记与五价锑药物使用相关的广泛临床表现和实验室发现。临床怀疑、早期诊断和积极治疗对于预防并发症和死亡至关重要。
