Inserm, UMS 011, Population-based Epidemiological Cohorts, Villejuif, France.
Inserm, UMS 011, Population-based Epidemiological Cohorts, Villejuif, France; Inserm, UMR 1168, VIMA, Villejuif, France; AP-HP, Hôpitaux Universitaires Paris Ouest, Centre Ambulatoire d'Addictologie, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France.
Addict Behav. 2019 Mar;90:85-91. doi: 10.1016/j.addbeh.2018.10.021. Epub 2018 Oct 16.
To examine the cross-sectional and longitudinal associations between depressive symptoms and electronic cigarette (e-cig) use in a large population-based sample while taking into account smoking status and sociodemographic confounders.
Participants from the French Constances cohort were included from February 2012 to December 2016. Smoking status, e-cig use (never/ever/current) and nicotine concentration were self-reported. Depressive symptoms were measured with the Center for Epidemiologic Studies Depression (CES-D) scale. Logistic regressions were used to provide odds ratios (ORs) and 95% confidence intervals (95%CI) of e-cig use according to depressive symptoms, adjusting for age, sex and education.
In cross-sectional analyses (n = 35,337), depressive symptoms (i.e. a CES-D score ≥ 19) were associated with both ever (OR [95%CI]: 1.67 [1.53-1.82]) and current (1.73 [1.53-1.96]) e-cig use with a dose-dependent relationship (p-trend<0.001). In longitudinal analyses (n = 30,818), depressive symptoms at baseline were associated with current e-cig use at follow-up (2.02 [1.72-2.37]) with a similar dose-dependent relationship. These associations were mainly significant among smokers or former smokers at baseline. Furthermore, among smokers at baseline, depressive symptoms were associated with dual consumption at follow-up (1.58 [1.41-1.77]), whereas among former smokers, they were associated with either smoking only (1.52 [1.34-1.73]) or e-cig use only (2.02 [1.64-2.49]), but not with dual consumption (1.11 [0.73-1.68]) at follow-up. Finally, depressive symptoms were positively associated with nicotine concentration among e-cig users at baseline.
Depressive symptoms were positively associated with e-cig use in both cross-sectional and longitudinal analyses with a dose-dependent relationship. In addition, nicotine concentration and depressive symptoms were positively associated.
在考虑吸烟状况和社会人口学混杂因素的情况下，在一个大型基于人群的样本中，研究抑郁症状与电子烟（电子烟）使用之间的横断面和纵向关联。
该研究纳入了 2012 年 2 月至 2016 年 12 月期间参加法国康斯坦茨队列的参与者。吸烟状况、电子烟使用情况（从未/曾经/当前）和尼古丁浓度均为自我报告。抑郁症状采用流行病学研究中心抑郁量表（CES-D）进行测量。使用逻辑回归提供了根据抑郁症状使用电子烟的比值比（OR）和 95%置信区间（95%CI），并调整了年龄、性别和教育。
在横断面分析中（n=35337），抑郁症状（即 CES-D 评分≥19）与曾经（OR [95%CI]：1.67 [1.53-1.82]）和当前（1.73 [1.53-1.96]）使用电子烟均相关，且呈剂量依赖性关系（p 趋势<0.001）。在纵向分析中（n=30818），基线时的抑郁症状与随访时的当前电子烟使用相关（2.02 [1.72-2.37]），呈相似的剂量依赖性关系。这些关联主要在基线时为吸烟者或曾经吸烟者中显著。此外，在基线时为吸烟者中，抑郁症状与随访时的双重使用相关（1.58 [1.41-1.77]），而在曾经吸烟者中，抑郁症状与仅吸烟（1.52 [1.34-1.73]）或仅使用电子烟（2.02 [1.64-2.49]）相关，但与随访时的双重使用无关（1.11 [0.73-1.68]）。最后，在基线时使用电子烟的人群中，抑郁症状与尼古丁浓度呈正相关。
在横断面和纵向分析中，抑郁症状与电子烟使用呈正相关，且与剂量呈依赖性关系。此外，尼古丁浓度和抑郁症状呈正相关。
