腺样体扁桃体切除术中阻塞性睡眠呼吸暂停非肥胖儿童半胱氨酰白三烯的尿浓度变化

Urine concentrations changes of cysteinyl leukotrienes in non-obese children with obstructive sleep apnea undergoing adenotonsillectomy.

作者信息

Mousailidis George Κ, Lachanas Vasileios A, Vasdeki Afroditi, Alexopoulos Emmanuel I, Kaditis Athanasios G, Petinaki Efthymia, Balatsos Nikolaos A A, Bizakis John G, Skoulakis Charalampos E

机构信息

Department of Otorhinolaryngology, University Hospital of Larissa, Greece.

出版信息

Int J Pediatr Otorhinolaryngol. 2018 Dec;115:149-152. doi: 10.1016/j.ijporl.2018.10.002. Epub 2018 Oct 4.

DOI:10.1016/j.ijporl.2018.10.002

PMID:30368376

Abstract

OBJECTIVE

The main objective of the study was to compare preoperative to postoperative levels of urine-Cysteinyl leukotrienes (uCysLT) in children undergoing adenotonsillectomy (AT) for obstructive sleep apnea (OSA) in order to investigate whether exaggerated leukotriene activity is the cause or consequence of OSA.

METHODS AND MATERIALS

A prospective study was conducted on non-obese children (4-10 years old) referred for overnight PSG. Children with moderate/severe OSA treated with AT were included. A second PSG study performed 2 months postoperatively to confirm OSA resolution, and those with residual OSA were excluded. Morning urine specimens after both PSG studies were obtained and pre-operative uCysLT levels were compared to postoperative levels.

RESULTS

27 children fulfilled the criteria and underwent a post-operative PSG study with three exclusions for residual OSA (postop-AHI>2), so the study group consisted of 24 children (mean age: 5.7 ± 2.1 years). Mean preoperative and postoperative AHI was 10.96 ± 5.93 and 1.44 ± 0.56 respectively. Mean preop-uCysLT were 21.14 ± 4.65, while after AT they significantly reduced to 12.62 ± 2.67 (P < 0.01).

CONCLUSION

uCysLT levels are significantly reduced after AT in non-obese children with moderate/severe OSA, suggesting that exaggerated leukotriene activity is mainly a consequence of OSA.

摘要

目的

本研究的主要目的是比较接受腺样体扁桃体切除术（AT）治疗阻塞性睡眠呼吸暂停（OSA）的儿童术前和术后尿半胱氨酰白三烯（uCysLT）水平，以调查白三烯活性增强是OSA的原因还是结果。

方法和材料

对因过夜多导睡眠图（PSG）检查而转诊的非肥胖儿童（4 - 10岁）进行前瞻性研究。纳入接受AT治疗的中度/重度OSA儿童。术后2个月进行第二次PSG检查以确认OSA是否缓解，残留OSA的儿童被排除。获取两次PSG检查后的晨尿标本，比较术前和术后uCysLT水平。

结果

27名儿童符合标准并接受了术后PSG检查，3名因残留OSA（术后呼吸暂停低通气指数>2）被排除，因此研究组由24名儿童组成（平均年龄：5.7 ± 2.1岁）。术前和术后平均呼吸暂停低通气指数分别为10.96 ± 5.93和1.44 ± 0.56。术前平均uCysLT为21.14 ± 4.65，而AT术后显著降至12.62 ± 2.67（P < 0.01）。