Erdoğan Ahmet, Düzgün Arife Polat, Erdoğan Kubra, Özkan Murat Bulut, Coşkun Faruk
Medical Doctor, Department of General Surgery, Ankara Numune Training and Research Hospital, Ankara, Turkey.
Medical Doctor and Professor, Department of General Surgery, Ankara Numune Training and Research Hospital, Ankara, Turkey.
J Foot Ankle Surg. 2018 Nov-Dec;57(6):1115-1119. doi: 10.1053/j.jfas.2018.05.011.
Diabetic foot ulcer is a common chronic complication of diabetes mellitus. In addition to conventional primary therapy, there are adjuvant therapy methods such as hyperbaric oxygen therapy for the healing of diabetic foot ulcer wounds. The present study aimed to determine the efficacy of hyperbaric oxygen therapy in diabetic foot ulcers based on Wagner classification. It was performed retrospectively from prospectively collected data. One hundred thirty patients with diabetic foot ulcers were assessed in 2 groups: 1 group received hyperbaric oxygen therapy; the other group did not. Patients were examined according to age, sex, ulcer grade based on Wagner classification; ulcer healing status; whether hyperbaric oxygen therapy was received; duration of diabetes in years; HbA1C, sedimentation, C-reactive protein levels; and presence of accompanying diseases, including peripheral arterial disease, chronic obstructive pulmonary disease, hypertension, chronic kidney disease, neuropathy, and retinopathy. The mean follow-up period was 19.5 ± 4.45 months (range 12 to 28 months). Seventy-one (54.6%) patients received hyperbaric oxygen therapy, and 59 (45.4%) patients did not. All patients in Wagner grade 2 healed in both groups. In the group that received hyperbaric oxygen therapy for grade 3 and 4 patients, 35 (87.5%) and 11 (84.6%) healed, respectively. In total, 60 (84.5%) patients in the group that received hyperbaric oxygen therapy healed. The subgroup comparison conducted according to Wagner classification revealed no differences between the 2 groups of grades 2 and 5 patients. It also revealed that treatment had higher levels of efficacy in the healing of ulcers in grade 3 and 4 patients.
糖尿病足溃疡是糖尿病常见的慢性并发症。除常规的主要治疗方法外，还有辅助治疗方法，如高压氧疗法用于糖尿病足溃疡伤口的愈合。本研究旨在根据瓦格纳分级确定高压氧疗法对糖尿病足溃疡的疗效。研究基于前瞻性收集的数据进行回顾性分析。130例糖尿病足溃疡患者被分为两组进行评估：一组接受高压氧治疗；另一组未接受。根据年龄、性别、基于瓦格纳分级的溃疡等级、溃疡愈合状况、是否接受高压氧治疗、糖尿病病程（以年计）、糖化血红蛋白、血沉、C反应蛋白水平以及是否存在伴随疾病（包括外周动脉疾病、慢性阻塞性肺疾病、高血压、慢性肾病、神经病变和视网膜病变）对患者进行检查。平均随访期为19.5±4.45个月（范围12至28个月）。71例（54.6%）患者接受了高压氧治疗，59例（45.4%）患者未接受。两组中所有瓦格纳2级患者均愈合。在接受高压氧治疗的3级和4级患者组中，分别有35例（87.5%）和11例（84.6%）愈合。接受高压氧治疗的组中共有60例（84.5%）患者愈合。根据瓦格纳分级进行的亚组比较显示，2级和5级患者的两组之间无差异。还显示治疗对3级和4级患者溃疡愈合的疗效更高。
