Kaya Ahmet, Aydin Figen, Altay Taskin, Karapinar Levent, Ozturk Hasan, Karakuzu Cengiz
Department of Orthopaedics and Traumatology, Tepecik Training and Research Hospital, Izmir, Turkey.
Int Orthop. 2009 Apr;33(2):441-6. doi: 10.1007/s00264-008-0623-y. Epub 2008 Jul 25.
Although hyperbaric oxygen therapy has been used for diabetic foot ulcer since the 1980s, there is little information on its efficacy. The aim of this study is to evaluate whether hyperbaric oxygen can decrease major amputation rates and to determine the predictive factors. A total of 184 consecutive patients were treated with hyperbaric oxygen therapy as an adjunct to standard treatment modalities for their diabetic foot ulcer. Of these patients, 115 were completely healed, 31 showed no improvement and 38 underwent amputation. Of the amputations, nine (4.9%) were major amputations (below knee) and 29 were minor. Major amputations were associated with the Wagner grade (p < 0.0001), with the age of the patients (p = 0.028) and with the age of the wounds (p = 0.018). Hyperbaric oxygen therapy can help to reduce the major amputation rates in diabetic foot ulcer. However, further large, multicentre, randomised controlled studies are needed to make more accurate conclusions.
自20世纪80年代以来，高压氧疗法就已用于治疗糖尿病足溃疡，但关于其疗效的信息却很少。本研究的目的是评估高压氧是否能降低大截肢率，并确定预测因素。共有184例连续性患者接受了高压氧治疗，作为其糖尿病足溃疡标准治疗方式的辅助治疗。在这些患者中，115例完全愈合，31例无改善，38例行截肢术。在截肢患者中，9例（4.9%）为大截肢（膝下），29例为小截肢。大截肢与Wagner分级（p<0.0001）、患者年龄（p=0.028）以及伤口年龄（p=0.018）相关。高压氧疗法有助于降低糖尿病足溃疡的大截肢率。然而，需要进一步开展大规模、多中心、随机对照研究，以得出更准确的结论。
