[内皮微粒在过敏性紫癜患儿中的表达及意义]
[Expression and significance of endothelial microparticles in children with Henoch-Schönlein purpura].
作者信息
Fu Shu-Qin, Guo Yan-Jun, Song Chun-Lan
机构信息
Children's Hospital of Zhengzhou University/Children's Hospital of Henan Province/Zhengzhou Children's Hospital/Zhengzhou Children's Critical Medical Key Laboratory, Zhengzhou 450000, China.
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2018 Oct;20(10):831-834. doi: 10.7499/j.issn.1008-8830.2018.10.009.
OBJECTIVE
To study the expression and significance of endothelial microparticles (EMPs) in children with Henoch-Schönlein purpura (HSP).
METHODS
A total of 100 previously untreated children with HSP were classified to Henoch-Schönlein purpura nephritis (HSPN) group (n=40) and non-nephritis group (n=60). Thirty healthy children who underwent physical examination were enrolled as control group. Serum levels of EMPs, T helper 17 cells (Th17), and interleukin-17 (IL-17) were compared between groups.
RESULTS
The HSPN and non-nephritis groups had significantly higher levels of Th17 and IL-17 than the control group, and the HSPN group had the highest levels (P<0.05). The HSPN and non-nephritis groups had a significantly higher level of EMPs than the control group, and the HSPN group had the highest level (P<0.05). In the HSPN group, the levels of Th17 and IL-17 were positively correlated with the level of EMPs (r=0.830 and 0.644 respectively; P<0.05).
CONCLUSIONS
EMPs play an important role in the pathogenesis of HSP. The increase in EMPs might be one of the reasons for renal involvement in children with HSP.
目的
研究内皮微粒（EMPs）在过敏性紫癜（HSP）患儿中的表达及意义。
方法
选取100例未经治疗的HSP患儿，分为紫癜性肾炎（HSPN）组（n = 40）和非肾炎组（n = 60）。选取30例健康体检儿童作为对照组。比较各组血清中EMPs、辅助性T细胞17（Th17）及白细胞介素-17（IL-17）水平。
结果
HSPN组和非肾炎组Th17及IL-17水平均显著高于对照组，且HSPN组最高（P < 0.05）。HSPN组和非肾炎组EMPs水平均显著高于对照组，且HSPN组最高（P < 0.05）。在HSPN组中，Th17及IL-17水平与EMPs水平呈正相关（r分别为0.830和0.644；P < 0.05）。
结论
EMPs在HSP发病机制中起重要作用。EMPs增加可能是HSP患儿肾脏受累的原因之一。
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