Fu Shu-Qin, Guo Yan-Jun, Song Chun-Lan
Children's Hospital of Zhengzhou University/Children's Hospital of Henan Province/Zhengzhou Children's Hospital/Zhengzhou Children's Critical Medical Key Laboratory, Zhengzhou 450000, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2018 Oct;20(10):831-834. doi: 10.7499/j.issn.1008-8830.2018.10.009.
To study the expression and significance of endothelial microparticles (EMPs) in children with Henoch-Schönlein purpura (HSP).
A total of 100 previously untreated children with HSP were classified to Henoch-Schönlein purpura nephritis (HSPN) group (n=40) and non-nephritis group (n=60). Thirty healthy children who underwent physical examination were enrolled as control group. Serum levels of EMPs, T helper 17 cells (Th17), and interleukin-17 (IL-17) were compared between groups.
The HSPN and non-nephritis groups had significantly higher levels of Th17 and IL-17 than the control group, and the HSPN group had the highest levels (P<0.05). The HSPN and non-nephritis groups had a significantly higher level of EMPs than the control group, and the HSPN group had the highest level (P<0.05). In the HSPN group, the levels of Th17 and IL-17 were positively correlated with the level of EMPs (r=0.830 and 0.644 respectively; P<0.05).
EMPs play an important role in the pathogenesis of HSP. The increase in EMPs might be one of the reasons for renal involvement in children with HSP.
研究内皮微粒（EMPs）在过敏性紫癜（HSP）患儿中的表达及意义。
选取100例未经治疗的HSP患儿，分为紫癜性肾炎（HSPN）组（n = 40）和非肾炎组（n = 60）。选取30例健康体检儿童作为对照组。比较各组血清中EMPs、辅助性T细胞17（Th17）及白细胞介素-17（IL-17）水平。
HSPN组和非肾炎组Th17及IL-17水平均显著高于对照组，且HSPN组最高（P < 0.05）。HSPN组和非肾炎组EMPs水平均显著高于对照组，且HSPN组最高（P < 0.05）。在HSPN组中，Th17及IL-17水平与EMPs水平呈正相关（r分别为0.830和0.644；P < 0.05）。
EMPs在HSP发病机制中起重要作用。EMPs增加可能是HSP患儿肾脏受累的原因之一。
