Department of Orthopedics, Shanxi Dayi Hospital, Taiyuan, Shanxi 030032, China.
Department of Endocrinology, the First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China
Biosci Rep. 2018 Nov 30;38(6). doi: 10.1042/BSR20181619. Print 2018 Dec 21.
This meta-analysis and systematic review was performed with the aim of investigating the association between a disintegrin and metalloproteinase with thrombospondin motif (ADAMTS)4, AMDMTS5 polymorphisms and risk of musculoskeletal degenerative diseases.
PubMed, EMBASE, ISI Web of Science, Wanfang and CNKI were searched from their inception until May 2018 to identify eligible studies. Data from individual studies were extracted using a standardized data collection sheet. The estimate of association between ADAMTS4, AMDMTS5 polymorphisms and risk of musculoskeletal degenerative diseases was expressed as odds ratio (OR) along with its related 95% confidence interval (95%CI) under an allelic model of inheritance. Meta-analysis was conducted using RevMan 5.3 software. Subgroup-analyses by ethnicity and type of diseases were performed.
Eight studies including ten cohorts were included in this meta-analysis. The meta-analyses results based on seven studies showed that rs226794 in ADAMTS5 gene was not associated with risk of musculoskeletal degenerative diseases (A vs. G: OR 1.07; 95%CI 0.97-1.19; =0.16). Rs2830585 in ADAMTS5 was significantly associated with musculoskeletal degenerative diseases in only Asians (OR 1.41, 95%CI 1.18-1.68; =0.0001), but not in Caucasians. Since only two of the collected studies referred to ADAMTS4, we did not perform meta-analysis for these comparisons.
Taken together, rs226794 and rs2830585 in ADAMTS5 gene were not associated with musculoskeletal degenerative diseases in overall population, but there seemed to be an ethnicity-dependent effect of rs2830585 in the risk of musculoskeletal degenerative diseases. Insufficient evidence was found to support the association of other single nucleotide polymorphisms and musculoskeletal degenerative diseases.
本荟萃分析和系统评价旨在研究解整合素金属蛋白酶与凝血酶样金属蛋白酶 4（ADAMTS4）、ADAMTS5 多态性与肌肉骨骼退行性疾病风险之间的关系。
从建库起至 2018 年 5 月，我们在 PubMed、EMBASE、ISI Web of Science、万方和中国知网（CNKI）中检索了符合条件的研究。使用标准化数据采集表提取来自各个研究的数据。ADAMTS4、ADAMTS5 多态性与肌肉骨骼退行性疾病风险之间的关联估计值用遗传的等位基因模型表示为比值比（OR）及其相关的 95%置信区间（95%CI）。使用 RevMan 5.3 软件进行荟萃分析。按种族和疾病类型进行亚组分析。
这项荟萃分析纳入了 8 项研究共 10 个队列。基于 7 项研究的荟萃分析结果显示，ADAMTS5 基因中的 rs226794 与肌肉骨骼退行性疾病的风险无关（A 对 G：OR 1.07；95%CI 0.97-1.19；=0.16）。仅在亚洲人中，ADAMTS5 中的 rs2830585 与肌肉骨骼退行性疾病显著相关（OR 1.41，95%CI 1.18-1.68；=0.0001），而在白种人中则不然。由于所收集的研究中仅有两项涉及 ADAMTS4，因此我们未对这些比较进行荟萃分析。
总的来说，ADAMTS5 基因中的 rs226794 和 rs2830585 与总体人群的肌肉骨骼退行性疾病无关，但 rs2830585 似乎对肌肉骨骼退行性疾病的风险存在种族依赖性效应。没有足够的证据支持其他单核苷酸多态性与肌肉骨骼退行性疾病之间的关联。
