Bahar Md Entaz, Hwang Jin Seok, Ahmed Mahmoud, Lai Trang Huyen, Pham Trang Minh, Elashkar Omar, Akter Kazi-Marjahan, Kim Dong-Hee, Yang Jinsung, Kim Deok Ryong
Department of Biochemistry and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52727, GyeongNam, Korea.
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju 52828, GyeongNam, Korea.
Antioxidants (Basel). 2022 Aug 14;11(8):1571. doi: 10.3390/antiox11081571.
Intervertebral disc degeneration (IVDD) is a prevalent cause of low back pain. IVDD is characterized by abnormal expression of extracellular matrix components such as collagen and aggrecan. In addition, it results in dysfunctional growth, senescence, and death of intervertebral cells. The biological pathways involved in the development and progression of IVDD are not fully understood. Therefore, a better understanding of the molecular mechanisms underlying IVDD could aid in the development of strategies for prevention and treatment. Autophagy is a cellular process that removes damaged proteins and dysfunctional organelles, and its dysfunction is linked to a variety of diseases, including IVDD and osteoarthritis. In this review, we describe recent research findings on the role of autophagy in IVDD pathogenesis and highlight autophagy-targeting molecules which can be exploited to treat IVDD. Many studies exhibit that autophagy protects against and postpones disc degeneration. Further research is needed to determine whether autophagy is required for cell integrity in intervertebral discs and to establish autophagy as a viable therapeutic target for IVDD.
椎间盘退变（IVDD）是下腰痛的常见原因。IVDD的特征是细胞外基质成分如胶原蛋白和聚集蛋白聚糖的异常表达。此外，它还会导致椎间盘细胞生长功能失调、衰老和死亡。IVDD发生和发展所涉及的生物学途径尚未完全明确。因此，更好地理解IVDD的分子机制有助于制定预防和治疗策略。自噬是一种清除受损蛋白质和功能失调细胞器的细胞过程，其功能障碍与包括IVDD和骨关节炎在内的多种疾病有关。在这篇综述中，我们描述了自噬在IVDD发病机制中的作用的最新研究发现，并强调了可用于治疗IVDD的自噬靶向分子。许多研究表明自噬可预防和延缓椎间盘退变。需要进一步研究以确定自噬是否是椎间盘细胞完整性所必需的，并将自噬确立为IVDD的可行治疗靶点。
