Taguchi Hiroyuki, Tanaka Haruki, Hashizaki Kaname, Saito Yoshihiro, Fujii Makiko
School of Pharmacy, Nihon University.
Biol Pharm Bull. 2019 Jan 1;42(1):116-122. doi: 10.1248/bpb.b18-00711. Epub 2018 Oct 23.
The emulsion prepared with β-cyclodextrin as an emulsifier (βCDE) is considered to be a Pickering emulsion. We examined the characteristics of βCDEs using captopril (CP) as a model drug, and studied the in vitro skin permeation of CP from βCDEs through hairless mouse skin. The stability of βCDE was increased with increasing βCD concentration and conversely decreased with increasing CP concentration. The yield stress value from the rheological measurement results was suggested to be one of the factors determining the stability of the βCDE, and βCDEs with higher yield stress values were more stable. We found that the skin permeability of CP could be improved by using βCDE with isopropyl myristate as the oil phase and that the flux of CP depended on the free CP concentration in the water phase of βCDE.
以β-环糊精作为乳化剂制备的乳剂（βCDE）被认为是一种皮克林乳液。我们以卡托普利（CP）作为模型药物研究了βCDE的特性，并研究了CP从βCDE透过无毛小鼠皮肤的体外皮肤渗透情况。βCDE的稳定性随βCD浓度的增加而提高，相反随CP浓度的增加而降低。流变学测量结果得出的屈服应力值被认为是决定βCDE稳定性的因素之一，屈服应力值较高的βCDE更稳定。我们发现，以肉豆蔻酸异丙酯作为油相使用βCDE可提高CP的皮肤渗透性，且CP的通量取决于βCDE水相中的游离CP浓度。
