Jug Mario, Yoon Bo Kyeong, Jackman Joshua A
Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovačića 1, Zagreb, Croatia.
School of Chemical Engineering and Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon, 16419 Republic of Korea.
J Incl Phenom Macrocycl Chem. 2021;101(1-2):31-50. doi: 10.1007/s10847-021-01097-z. Epub 2021 Aug 3.
Cyclodextrins (CDs) are biocompatible, cyclic oligosaccharides that are widely used in various industrial applications and have intriguing interfacial science properties. While CD molecules typically have low surface activity, they are capable of stabilizing emulsions by inclusion complexation of oil-phase components at the oil/water interface, which results in Pickering emulsion formation. Such surfactant-free formulations have gained considerable attention in recent years, owing to their enhanced physical stability, improved tolerability, and superior environmental compatibility compared to conventional, surfactant-based emulsions. In this review, we critically describe the latest insights into the molecular mechanisms involved in CD stabilization of Pickering emulsions, including covering practical aspects such as methods to prepare CD-based Pickering emulsions, lipid encapsulation, and relevant stability issues. In addition, the rheological and textural features of CD-based Pickering emulsions are discussed and particular attention is focused on promising examples for drug delivery, cosmetic, and nutraceutical applications. The functionality of currently developed CD-based Pickering emulsions is also summarised, including examples such as antifungal uses, and we close by discussing emerging possibilities to utilize the molecular encapsulation of CD-based emulsions for translational medicine applications in the antiviral and antibacterial spaces.
环糊精（CDs）是具有生物相容性的环状寡糖，广泛应用于各种工业领域，具有引人关注的界面科学特性。虽然CD分子通常表面活性较低，但它们能够通过在油/水界面处对油相成分进行包合络合来稳定乳液，从而形成皮克林乳液。近年来，这种无表面活性剂的配方因其相较于传统的基于表面活性剂的乳液具有更高的物理稳定性、更好的耐受性和更优异的环境相容性而备受关注。在这篇综述中，我们批判性地阐述了关于CD稳定皮克林乳液所涉及分子机制的最新见解，包括制备基于CD的皮克林乳液的方法、脂质包封以及相关稳定性问题等实际方面。此外，还讨论了基于CD的皮克林乳液的流变学和质地特性，并特别关注了在药物递送、化妆品和营养保健品应用方面有前景的实例。还总结了当前开发的基于CD的皮克林乳液的功能，包括抗真菌用途等实例，最后我们讨论了利用基于CD的乳液的分子包封在抗病毒和抗菌领域进行转化医学应用的新可能性。
