Khatri Shradha, Sabeena Sasidharanpillai, Arunkumar G, Mathew Mary
1Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka 576104 India.
2Manipal Centre for Virus Research, Manipal Academy of Higher Education, Manipal, Karnataka 576104 India.
Indian J Hematol Blood Transfus. 2018 Oct;34(4):703-706. doi: 10.1007/s12288-018-0924-2. Epub 2018 Jan 23.
Worldwide, there is a rise in the incidence of dengue infection associated with multiple serotypes. Epidemiological studies have reported a higher incidence of severe dengue in secondary dengue infections. A rapid fall in platelet count associated with an increase in hematocrit above the baseline is one of the warning signs of plasma leakage. This study was undertaken to determine the utility of platelet indices such as mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit in dengue fever cases with thrombocytopenia. A hospital-based cross-sectional study was carried out between April and September 2014, among dengue patients with thrombocytopenia using platelet histograms. The study population included all the laboratory confirmed cases of dengue infection with thrombocytopenia admitted at Kasturba Medical College, Manipal, Karnataka during the study period. The blood samples collected from serologically confirmed dengue patients with thrombocytopenia were analyzed using automated analyzer within 2 h of venipuncture. The platelet histograms (MPV, PDW, Plateletcrit) generated by the Beckman Coulter counter LH755™ and LH780™ series were assessed in dengue fever cases with thrombocytopenia. The mean platelet volume (MPV) was observed to be 9.01 fL (SD = 0.09). The mean platelet distribution width and median plateletcrit were 17.2% (SD = 0.98) and 0.47 (IQR 0.2-0.8) respectively. None of the study participants presented with bleeding manifestations. The present study revealed no significant changes of platelet parameters in dengue cases with thrombocytopenia.
在全球范围内，与多种血清型相关的登革热感染发病率呈上升趋势。流行病学研究报告称，二次登革热感染中严重登革热的发病率更高。血小板计数迅速下降并伴有血细胞比容高于基线水平是血浆渗漏的警示信号之一。本研究旨在确定血小板指数，如平均血小板体积（MPV）、血小板分布宽度（PDW）和血小板压积在血小板减少的登革热病例中的作用。2014年4月至9月间，在血小板减少的登革热患者中开展了一项基于医院的横断面研究，使用血小板直方图进行分析。研究人群包括在研究期间入住卡纳塔克邦马尼帕尔卡斯图尔巴医学院的所有实验室确诊的血小板减少的登革热感染病例。对血清学确诊的血小板减少的登革热患者采集的血样在静脉穿刺后2小时内使用自动分析仪进行分析。对贝克曼库尔特LH755™和LH780™系列血细胞分析仪生成的血小板直方图（MPV、PDW、血小板压积）在血小板减少的登革热病例中进行评估。观察到平均血小板体积（MPV）为9.01飞升（标准差=0.09）。平均血小板分布宽度和血小板压积中位数分别为17.2%（标准差=0.98）和0.47（四分位距0.2 - 0.8）。没有研究参与者出现出血表现。本研究显示血小板减少的登革热病例中血小板参数无显著变化。
