Chatterjee Nandini, Mukhopadhyay Mainak, Ghosh Sinjon, Mondol Manas, Das Chiranjib, Patar Kartik
J Assoc Physicians India. 2014 Mar;62(3):224-7.
Dengue fever (DF) has become a significant resurgent tropical disease in the past 20 years all over the globe. The recent outbreak in West Bengal has once again underlined our failure in vector control and prevention. Our study outlines the clinical spectrum as well as the geographical expansion of the disease beyond urban confines.
All patients with acute febrile illness positive for IgM antibody for Dengue virus were taken as cases. The patients were subjected to clinical examination and baseline investigations so as to fill in a structured proforma.
The total number of patients were 180 of whom 92 (51.1%) were male and 88 (48.9%) were female. The maximum number of patients belonged to the age group 20-29 years (26.9%). The patients mostly hailed from Kolkata followed by Nadia, 24- Parganas(S), Murshidabad and Midnapur. The most common presentation apart from fever and bodyache were gastrointestinal symptoms. 42% patients complained of abdominal pain, 24% had vomiting, 9.6% diarrhoea. Bleeding manifestations occurred in 23% of patients. CNS features were documented 10.4%. Case fatality came out to be 3.8%. Investigations revealed thrombocytopenia in 55% and leucopenia 32.7%, transaminitis in 72% Evidence of organomegaly (22.2%) and serositis (42%) were detected. Complications included intracranial haemorrhage, DIC, pancreatitis, myocarditis and even a solitary case of splenic rupture.
The current outbreak was affecting both the genders equitably and mostly the younger age group from rural as well as urban areas. A febrile illness characterised by myalgia, mild bleeding and gastrointestinal symptoms, it was more or less promptly responsive to early conservative therapy like fluids, FFP and platelet transfusion where required.
在过去20年里，登革热已成为全球范围内一种显著复苏的热带疾病。西孟加拉邦最近的疫情再次凸显了我们在病媒控制和预防方面的失败。我们的研究概述了该疾病的临床谱以及其在城市范围之外的地理扩散情况。
所有登革病毒IgM抗体检测呈阳性的急性发热性疾病患者均被视为病例。对患者进行临床检查和基线调查，以便填写一份结构化的表格。
患者总数为180人，其中男性92人（51.1%），女性88人（48.9%）。患者人数最多的年龄组为20 - 29岁（26.9%）。患者大多来自加尔各答，其次是纳迪亚、24 - 帕尔加纳（南）、默西达巴德和米德纳布尔。除发热和身体疼痛外，最常见的症状是胃肠道症状。42%的患者主诉腹痛，24%有呕吐，9.6%有腹泻。23%的患者出现出血表现。记录到中枢神经系统症状的占10.4%。病死率为3.8%。检查发现55%的患者有血小板减少，32.7%有白细胞减少，72%有转氨酶升高。检测到有器官肿大（22.2%）和浆膜炎（42%）的证据。并发症包括颅内出血、弥散性血管内凝血、胰腺炎、心肌炎，甚至有一例脾破裂。
当前疫情对男女影响相当，主要影响农村和城市地区的年轻年龄组。这种以肌痛、轻度出血和胃肠道症状为特征的发热性疾病，在需要时，对早期保守治疗如补液、新鲜冷冻血浆和血小板输注等反应或多或少较为迅速。
