Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Department of Pharmacy, he First Affiliated Hospital of Harbin Medical University, Harbin, China.
J Biochem Mol Toxicol. 2019 Feb;33(2):e22246. doi: 10.1002/jbt.22246. Epub 2018 Oct 28.
Trimethylamine N-oxide (TMAO) is an independent risk factor of cardiovascular disease. Our objective was to explore the relation between TMAO and ischemic stroke (IS) in patients with atrial fibrillation (AF). A total of 68 patients with AF with IS and 111 ones without IS were enrolled. The plasma levels of TMAO remarkably increased in IS-AF patients (8.25 ± 1.58 µM) compared with patients with AF (2.22 ± 0.09 µM, P < 0.01). The receiver operating characteristic analysis revealed that the best cutoff value of TMAO to predict IS in patients with AF was 3.53 µM with 75.0% sensitivity and 92.8% specificity (area under the curve: 0.917, 95% confidence intervals: 0.877-0.957). Univariate and multivariate logistic regression analysis showed that TMAO was an independent predictor in IS. The level of TMAO was correlated with the CHA2DS2-VASc score. In conclusion, TMAO was an independent predictor of IS, which could potentially refine stroke stratification in patients with AF.
氧化三甲胺（TMAO）是心血管疾病的独立危险因素。我们的目的是探讨 TMAO 与房颤（AF）患者缺血性卒中（IS）的关系。共纳入 68 例伴 IS 的 AF 患者和 111 例不伴 IS 的 AF 患者。IS-AF 患者的 TMAO 水平明显升高（8.25±1.58µM），与 AF 患者（2.22±0.09µM，P<0.01）相比。受试者工作特征分析显示，TMAO 预测 AF 患者 IS 的最佳截断值为 3.53µM，具有 75.0%的敏感性和 92.8%的特异性（曲线下面积：0.917，95%置信区间：0.877-0.957）。单因素和多因素 logistic 回归分析表明，TMAO 是 IS 的独立预测因子。TMAO 水平与 CHA2DS2-VASc 评分相关。总之，TMAO 是 IS 的独立预测因子，可能有助于对 AF 患者进行卒中分层。
