School of Biomedical Engineering, Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, Sun Yat-sen University, No. 132, East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou, 510006, People's Republic of China.
Nanotechnology. 2019 Jan 4;30(1):015101. doi: 10.1088/1361-6528/aae6aa. Epub 2018 Oct 29.
Various nanoformulations of perfluorocarbon have been developed thus far, to achieve ultrasound imaging of tumors and tumor-targeted therapy. However, their application has been greatly limited by their short sonographic duration and large size distribution. A novel theranostic agent was constructed based on gold nanoshell cerasome-encapsulated L-menthol (GNC-LM). Owing to the sustained and controllable generation of L-menthol bubbles under near-infrared laser irradiation, GNC-LM showed good performance in contrast enhancement of ultrasound imaging in vivo. GNC-LM could be imaged for 30 min, which is much longer than the imaging time of SonoVue (commercially used microbubbles). Moreover, photothermal therapy (PTT) based on the light-to-heat conversion of the nanosystem effectively ablated the tumor. Our study demonstrated the promising potential of the obtained GNC-LM to serve as a therapeutic nanoprobe for ultrasound contrast imaging and PTT of tumors.
迄今为止，已经开发出了各种氟碳纳米制剂，以实现肿瘤的超声成像和肿瘤靶向治疗。然而，由于它们的超声持续时间短和粒径分布大，它们的应用受到了很大的限制。基于金纳米壳脂质体包裹 L-薄荷醇（GNC-LM）构建了一种新型治疗剂。由于在近红外激光照射下能够持续且可控地产生 L-薄荷醇气泡，因此 GNC-LM 在体内超声成像的对比增强方面表现出良好的性能。GNC-LM 的成像时间可长达 30 分钟，比 SonoVue（市售的微泡）的成像时间长得多。此外，基于纳米系统的光热转换的光热疗（PTT）有效地消融了肿瘤。我们的研究表明，所获得的 GNC-LM 作为治疗性纳米探针用于肿瘤的超声对比成像和 PTT 具有广阔的应用前景。
