Restorative Effect of Semecarpus Anacardium on Altered Energy Metabolism in Type-2 Diabetes Mellitus-Induced Cardiac Dysfunction in Rats.

Semecarpus anacardium is an important herbal drug that has been used against various ailments. To evaluate the cardioprotective effect of the drug against altered cardiac energy metabolism in type-2 diabetes rats, type-2 diabetes was induced in rats by feeding them with a high-fat diet for 2 weeks followed by intraperitoneal injection of streptozotocin (STZ) 35 mg/kg body weight twice 24 h apart and left for 12 weeks to develop cardiovascular complication. The effects of the nut milk extract on the glucose metabolizing enzymes and mitochondrial complex enzymes were studied using biochemical assays. The drug effectively ameliorated the alteration in cardiac energy metabolism in diabetic rats. The cardioprotective effect may be mediated through the ability of the drug to enhance glucose utilization and control the oxidative stress under diabetic conditions.