School of Nursing, National Yang-Ming University, Taipei, Taiwan.
Department of Nursing, Cardinal Tien College of Healthcare and Management, New Taipei City, Taiwan.
J Adv Nurs. 2019 Mar;75(3):640-651. doi: 10.1111/jan.13881. Epub 2019 Feb 11.
To determine whether acupressure can prevent or relieve the adverse drug reactions (ADRs) of anti-tuberculosis drugs.
People receiving drug treatment for TB often experience ADRs that may cause them to stop taking their medication. Acupressure is a form of traditional Chinese medicine that can be applied to alleviate or prevent disease symptoms.
A double-blinded, repeated-measures clinical trial in hospitals in Taiwan was carried out from April 2015 - May 2017.
Convenience sampling was used to select 32 people (15 for the experimental group and 17 for the control group) aged >20 years who were taking anti-tuberculosis drugs. The people were randomized to receive 4-week of true acupressure and 4-weeks of sham acupressure. Acupressure therapy was given by a researcher in all cases. Both groups received treatment once per day on weekdays, with 15 min for each acupressure session. Outcomes (gastrointestinal irritation and adverse skin reactions) were assessed according to the people feedback and the physicians' recordings during the treatment course, and during monthly follow-up visits for 6 months thereafter.
Both groups typically experienced gastrointestinal irritation and adverse skin reactions within 2 months of beginning anti-tuberculosis drug treatment. The 4-weeks intervention involving relevant acupressure points successfully relieved both types of side effects in both immediate and delayed manner.
When correctly implemented, acupressure can prevent and relieve the ADRs of anti-tuberculosis drugs, and motivate people to complete their treatment course.
确定按压穴位是否可以预防或缓解抗结核药物的不良反应（ADR）。
接受结核病药物治疗的人经常会出现 ADR，这可能导致他们停止服药。穴位按压是一种传统的中医形式，可以应用于缓解或预防疾病症状。
2015 年 4 月至 2017 年 5 月，在台湾的医院进行了一项双盲、重复测量的临床试验。
采用便利抽样法，选取 32 名年龄>20 岁、正在服用抗结核药物的患者（实验组 15 人，对照组 17 人）。将这些人随机分为真穴位按压组和假穴位按压组，各 4 周。穴位按压疗法由研究人员在所有情况下进行。两组患者均在工作日每天接受一次治疗，每次穴位按压 15 分钟。根据患者在治疗过程中的反馈和医生的记录，以及此后 6 个月的每月随访，评估结果（胃肠道刺激和皮肤不良反应）。
两组患者在开始抗结核药物治疗后 2 个月内通常会出现胃肠道刺激和皮肤不良反应。涉及相关穴位的 4 周干预措施成功地立即和延迟缓解了这两种类型的副作用。
正确实施穴位按压可以预防和缓解抗结核药物的不良反应，促使患者完成治疗过程。
