含吩嗪-1-羧酸骨架的 1,3,4-噁二唑-2-基硫醚衍生物的合成与杀菌活性。
Synthesis and fungicidal activity of 1,3,4-oxadiazol-2-yl thioether derivatives containing a phenazine-1-carboxylic acid scaffold.
机构信息
a School of Agriculture , Yangtze University , Jingzhou , China.
b Institute of Pesticides , Yangtze University , Jingzhou , China.
出版信息
Nat Prod Res. 2019 Aug;33(15):2145-2150. doi: 10.1080/14786419.2018.1489389. Epub 2018 Oct 30.
To find new higher fungicidal activities lead compounds and develop new eco-friendly agrochemicals, natural product phenazine-1-carboxylic acid (PCA) as scaffold, a series of 1,3,4-oxadiazol-2-yl thioether derivatives was synthesized and bio-assayed. The results reveal that most target compounds possessed moderate to good fungicidal activities against , and Compounds and exhibit more than 90% bioactivity against . The EC value of compounds and are 11.16 and 30.47 μM respectively, in particular, compound show equal activity against to PCA (10.49 μM). This result provides a valuable lead compound for further studies.
为了寻找具有更高杀菌活性的先导化合物并开发新的环保型农用化学品，以天然产物吩嗪-1-羧酸（PCA）为骨架，合成了一系列 1,3,4-噁二唑-2-基硫醚衍生物，并进行了生物活性测定。结果表明，大多数目标化合物对 、 和 具有中等至良好的杀菌活性。化合物 和 对 的生物活性超过 90%。化合物 和 的 EC 值分别为 11.16 和 30.47 μM，特别是化合物 对 的活性与 PCA（10.49 μM）相当。该结果为进一步的研究提供了有价值的先导化合物。
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