强直性脊柱炎患者肾结石的风险：一项基于人群的队列研究。
The Risk of Nephrolithiasis Among Patients With Ankylosing Spondylitis: a Population-Based Cohort Study.
作者信息
Shih Mu Tsun, Tang Shou Hung, Cha Tai Lung, Wu Sheng Tang, Chiang Jen Huai, Chen Wen Chi
机构信息
Division of Urology, Department of Surgery, Tri-service General Hospital, National Defence Medical Center, Taipei City, Taiwan.
Graduate Institute of Integrated Medicine, College of Chinese Medicine, College of Medicine, Research Center for Chinese Medicine & Acupuncture, China Medical University, Management Office for Health Data, China Medical University Hospital, Taichung City, Taiwan.
出版信息
Arch Rheumatol. 2016 Aug 1;31(4):346-352. doi: 10.5606/ArchRheumatol.2016.5938. eCollection 2016 Dec.
OBJECTIVES
This study aims to investigate the correlation of ankylosing spondylitis (AS) with nephrolithiasis by performing a nationwide population- based cohort study.
PATIENTS AND METHODS
The data used in this retrospective cohort study were collected from the Taiwan National Health Insurance Research database. The study included a total of 3,334 AS patients (1,914 males, 1,420 females; mean age 44.51±16.83 years; range 22 to 79 years) and 13,336 non-AS patients (7,656 males, 5,680 females; mean age 44.27±17.01 years; range 21 to 78 years) who had been followed-up on an average of 6.78 years and 6.75 years, respectively, between January 2000 and December 2008.
RESULTS
The percentage of newly diagnosed nephrolithiasis was 4.8% in all study subjects. However, the percentages of newly diagnosed nephrolithiasis were 5.76% and 4.58% in the AS and non-AS cohorts, respectively. After adjusting the patients' sex, age, urbanization level, and comorbidities, the hazard ratio obtained from our multivariable Cox model was 1.19.
CONCLUSION
Our study findings indicate that patients with AS are more likely to develop nephrolithiasis than non-AS patients.
目的
本研究旨在通过开展一项全国性基于人群的队列研究，调查强直性脊柱炎（AS）与肾结石的相关性。
患者与方法
本回顾性队列研究中使用的数据来自台湾国民健康保险研究数据库。该研究共纳入3334例AS患者（男性1914例，女性1420例；平均年龄44.51±16.83岁；年龄范围22至79岁）和13336例非AS患者（男性7656例，女性5680例；平均年龄44.27±17.01岁；年龄范围21至78岁），在2000年1月至2008年12月期间，他们分别平均随访了6.78年和6.75年。
结果
所有研究对象中新诊断肾结石的比例为4.8%。然而，AS队列和非AS队列中新诊断肾结石的比例分别为5.76%和4.58%。在对患者的性别、年龄、城市化水平和合并症进行调整后，我们的多变量Cox模型得出的风险比为1.19。
结论
我们的研究结果表明，AS患者比非AS患者更易患肾结石。
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