强直性脊柱炎患者患哮喘的风险：一项基于人群的队列研究。
The risk of asthma in patients with ankylosing spondylitis: a population-based cohort study.
作者信息
Shen Te-Chun, Lin Cheng-Li, Wei Chang-Ching, Chen Chia-Hung, Tu Chih-Yen, Hsia Te-Chun, Shih Chuen-Ming, Hsu Wu-Huei, Sung Fung-Chang
机构信息
Graduate Institute of Clinical Medicine Science, College of Medicine, China Medical University, Taichung, Taiwan; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Management Office for Health Data, China Medical University Hospital, China Medical University, Taichung, Taiwan.
出版信息
PLoS One. 2015 Feb 6;10(2):e0116608. doi: 10.1371/journal.pone.0116608. eCollection 2015.
BACKGROUND
The relationship between asthma and ankylosing spondylitis (AS) is controversial. We examined the risk of asthma among AS patients in a nationwide population.
METHODS
We conducted a retrospective cohort study using data from the National Health Insurance (NHI) system of Taiwan. The cohort included 5,974 patients newly diagnosed with AS from 2000 to 2010. The date of diagnosis was defined as the index date. A 4-fold of general population without AS was randomly selected frequency matched by age, gender and the index year. The occurrence and hazard ratio (HR) of asthma were estimated by the end of 2011.
RESULTS
The overall incidence of asthma was 1.74 folds greater in the AS cohort than in the non-AS cohort (8.26 versus 4.74 per 1000 person-years) with a multivariable Cox method measured adjusted HR of 1.54 (95% confidence interval (CI), 1.34-1.76). The adjusted HR of asthma associated with AS was higher in women (1.59; 95% CI, 1.33-1.90), those aged 50-64 years (1.66; 95% CI, 1.31-2.09), or those without comorbidities (1.82; 95% CI, 1.54-2.13).
CONCLUSION
Patients with AS are at a higher risk of developing asthma than the general population, regardless of gender and age. The pathophysiology needs further investigation.
背景
哮喘与强直性脊柱炎（AS）之间的关系存在争议。我们在全国范围内的人群中研究了AS患者患哮喘的风险。
方法
我们使用台湾国民健康保险（NHI）系统的数据进行了一项回顾性队列研究。该队列包括2000年至2010年新诊断为AS的5974例患者。诊断日期被定义为索引日期。随机选择4倍数量的无AS的普通人群，按年龄、性别和索引年份进行频率匹配。到2011年底估计哮喘的发生率和风险比（HR）。
结果
AS队列中哮喘的总体发病率比非AS队列高1.74倍（每1000人年分别为8.26和4.74），多变量Cox方法测量的调整后HR为1.54（95%置信区间（CI），1.34 - 1.76）。与AS相关的哮喘调整后HR在女性（1.59；95%CI，1.33 - 1.90）、50 - 64岁人群（1.66；95%CI，1.31 - 2.09）或无合并症人群（1.82；95%CI，1.54 - 2.13）中更高。
结论
AS患者患哮喘的风险高于普通人群，无论性别和年龄。其病理生理学需要进一步研究。
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