Suppr超能文献

日本献血者中丙型肝炎病毒感染的发病率:一项全国性回顾性队列研究。

Incidence rates of hepatitis C virus infection among blood donors in Japan: a nationwide retrospective cohort study.

作者信息

Uchida Shigeharu, Satake Masahiro, Kurisu Akemi, Sugiyama Aya, Ko Ko, Akita Tomoyuki, Tanaka Junko

机构信息

Central Blood Institute, Japanese Red Cross Society, Minato-ku, Tokyo, Japan.

Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences, Hiroshima University, Minami-ku, Hiroshima-shi, Japan.

出版信息

Transfusion. 2018 Dec;58(12):2880-2885. doi: 10.1111/trf.14951. Epub 2018 Oct 30.

Abstract

BACKGROUND

The classification of many new cases of hepatitis virus infection as overt hepatitis does not reflect the true incidence of infection because the disease takes an asymptomatic course in some cases. In this retrospective cohort study, we aimed to estimate the incidence rates of new hepatitis C virus (HCV) infections among the blood donors.

STUDY DESIGN AND METHOD

A 5-year retrospective cohort study was conducted to estimate the incidence rates by using the medical records of the blood donors between 2008 and 2013 for HCV infection. HCV seroconversions were investigated using a chemiluminescent enzyme immunoassay and then confirmed by nucleic acid amplification tests.

RESULTS

The incidence rate of HCV infection was 0.40 per 100,000 person-years (95% confidence interval, 0.27-0.57) for HCV RNA seroconversion only and 7.32 per 100,000 person-years (95% confidence interval, 6.73-7.95) if either HCV RNA or anti-HCV seroconversion were taken into consideration. No significant difference of new HCV infections was found between the sexes.

CONCLUSION

The incidence rate of HCV infection of this study was lower than that detected in a previous 1994-2004 study in which HCV incidence was 1.86 per 100,000 person-year, which reflects the presence of an effective blood screening system and health strategies targeting hepatitis control and prevention.

摘要

背景

许多新的肝炎病毒感染病例被归类为显性肝炎,这并不能反映感染的真实发生率,因为在某些情况下该疾病呈无症状病程。在这项回顾性队列研究中,我们旨在估计献血者中新发丙型肝炎病毒(HCV)感染的发生率。

研究设计与方法

进行了一项为期5年的回顾性队列研究,通过使用2008年至2013年期间献血者的医疗记录来估计HCV感染的发生率。使用化学发光酶免疫测定法调查HCV血清转化情况,然后通过核酸扩增试验进行确认。

结果

仅HCV RNA血清转化时,HCV感染的发生率为每10万人年0.40(95%置信区间,0.27 - 0.57);若考虑HCV RNA或抗-HCV血清转化,则发生率为每10万人年7.32(95%置信区间,6.73 - 7.95)。男女之间新发HCV感染无显著差异。

结论

本研究中HCV感染的发生率低于1994 - 2004年之前一项研究中检测到的发生率,之前研究中HCV发病率为每10万人年1.86,这反映了存在有效的血液筛查系统以及针对肝炎控制和预防的健康策略。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验