Department of Preventive Medicine and Epidemiology, National Cerebral and Cardiovascular Center Research Institute, 6-1 Kishibeshin-machi, Suita, Osaka, 564-8565, Japan.
Department of Health Care Administration and Management, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Environ Health. 2020 Nov 23;19(1):119. doi: 10.1186/s12940-020-00680-0.
In 1968, the Yusho incident resulted in accidental exposure to polychlorinated biphenyls (PCBs), polychlorinated dibenzofurans (PCDFs), and related compounds in Japan. This study updated the risk of mortality in Yusho patients.
We obtained updated cohort data for all Yusho patients for the period 1968-2017. We calculated standardized mortality ratios (SMRs) for all-cause and cause-specific mortality over a 50-year follow-up period compared with the general population in Japan.
A total of 1664 Yusho patients with 63,566 person-years of follow up were included in the analysis. Among males, excess mortality was observed for all cancers (SMR: 1.22, 95% confidence interval [CI]: 1.02 to 1.45) and lung cancer (SMR: 1.59, 95% CI: 1.12 to 2.19). Among females, increased mortality was observed for liver cancer (SMR: 2.05, 95% CI: 1.02 to 3.67). No significant increase was seen in non-cancer-related mortality compared with the general population.
Carcinogenic risk in humans after exposure to PCBs and PCDFs remains higher among Yusho patients. Our findings suggest the importance of care engagement and optimum management to deal with the burden of Yusho disease.
1968 年，日本发生了水俣病事件，导致人们意外暴露于多氯联苯（PCBs）、多氯二苯并呋喃（PCDFs）和相关化合物中。本研究更新了水俣病患者的死亡风险。
我们获得了 1968 年至 2017 年期间所有水俣病患者的最新队列数据。我们计算了在 50 年的随访期间，所有原因和特定原因死亡率的标准化死亡率比（SMR），并与日本的一般人群进行了比较。
共有 1664 名水俣病患者纳入了分析，随访时间为 63566 人年。在男性中，所有癌症（SMR：1.22，95%置信区间[CI]：1.02 至 1.45）和肺癌（SMR：1.59，95%CI：1.12 至 2.19）的死亡人数均高于预期。在女性中，肝癌（SMR：2.05，95%CI：1.02 至 3.67）的死亡率也有所增加。与一般人群相比，非癌症相关死亡率没有显著增加。
人类接触 PCBs 和 PCDFs 后致癌风险仍然较高。我们的研究结果表明，关注水俣病患者的健康并进行最佳管理对于应对水俣病的负担至关重要。
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