Cancer Registration and Statistic Branch, National Cancer Control Institute, National Cancer Center, Goyang, Korea.
Department of Preventive Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
Epidemiol Health. 2018;40:e2018052. doi: 10.4178/epih.e2018052. Epub 2018 Oct 26.
The Korea Central Cancer Registry conducted the National Epidemiologic Survey of Thyroid cancer (NEST) to investigate changes in the epidemiological and clinical characteristics of thyroid cancer patients between 1999 and 2008. The NEST was designed to collect representative samples of patients with thyroid cancer diagnosed in the years 1999, 2005, and 2008 using a proportionally stratified and systematic random sampling method. Among 42,891 participants diagnosed with thyroid cancer, 5,796 participants were included in the final study population. This survey collected information on diagnostic methods and date, route of diagnosis, prior medical history and history of thyroid-related disease, tumor, lymph node, metastasis and collaborative stage, and treatment. The NEST dataset was also linked to the cause-of-death database from Statistics Korea. The mean age of the study participants was 46.9 years. The ratio of men to women was 1:5.5. In the analysis of the histologic type of cancer, the proportion of papillary thyroid carcinoma showed an increasing trend (p<0.01). In contrast, the proportion of distant metastasis and the mean tumor size of thyroid cancers showed decreasing trends over time (p<0.01, respectively).
韩国中央癌症登记处开展了全国性的甲状腺癌流行病学调查（NEST），旨在研究 1999 年至 2008 年间甲状腺癌患者的流行病学和临床特征变化。NEST 采用比例分层和系统随机抽样方法，收集了 1999 年、2005 年和 2008 年确诊的甲状腺癌患者的代表性样本。在 42891 名甲状腺癌患者中，最终有 5796 名患者纳入研究人群。该调查收集了有关诊断方法和日期、诊断途径、既往病史和甲状腺相关疾病史、肿瘤、淋巴结、转移和协作分期以及治疗的信息。NEST 数据集还与韩国统计局的死因数据库进行了关联。研究参与者的平均年龄为 46.9 岁。男女比例为 1:5.5。在癌症组织学类型分析中，乳头状甲状腺癌的比例呈上升趋势（p<0.01）。相比之下，远处转移的比例和甲状腺癌的平均肿瘤大小随时间呈下降趋势（p<0.01，分别）。
