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[犊牛实验性酸中毒期间氮代谢及三羧酸循环各种底物水平的变化]

[Changes in the levels of various substrates of nitrogen metabolism and tricarboxylic acid cycle during experimental acidosis in calves].

作者信息

Mel'nichuk D A, Liubetskaia T V, Makarenko O N

出版信息

Ukr Biokhim Zh (1978). 1987 May-Jun;59(3):51-5.

PMID:3037745
Abstract

The effect of experimental metabolic acidosis and its correction for nitrogen and energy metabolism was studied in new-born calves. It was discovered that a change in the acid-base balance towards acidosis causes a sharp increase in "ammoniogenesis", urea formation and inhibition of the tricarboxylic acid cycle, which is also observed in calves suffering from dyspepsia with symptoms of acute diarrhea. Alongside with the use of therapeutic measures for treating dyspepsia of new-born calves, it is necessary to control the acid-base balance of blood in the calves and in case of revealing the acidosis state to use means of its correction.

摘要

在新生犊牛中研究了实验性代谢性酸中毒及其对氮和能量代谢的纠正作用。发现酸碱平衡向酸中毒方向变化会导致“氨生成”、尿素形成急剧增加以及三羧酸循环受到抑制,这在患有伴有急性腹泻症状的消化不良的犊牛中也有观察到。除了采用治疗新生犊牛消化不良的治疗措施外,有必要控制犊牛血液的酸碱平衡,一旦发现酸中毒状态,需采用纠正措施。

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