经皮自体骨髓注射治疗内固定后长骨骨折的延迟愈合或不愈合
Percutaneous autogenous bone marrow injection for delayed union or non-union of long bone fractures after internal fixation.
作者信息
Sahu Ramji Lal
机构信息
Department of Orthopaedics, Sharda University, Greater Noida, India.
出版信息
Rev Bras Ortop. 2017 Dec 29;53(6):668-673. doi: 10.1016/j.rboe.2017.09.004. eCollection 2018 Nov-Dec.
OBJECTIVES
The aim of this study was to assess the results of percutaneous injection of autologous bone marrow in the treatment of fractures presenting with delayed union or non-union after internal fixation.
METHODS
This prospective study was carried out at the Orthopeedics Department from June 2005 to June 2010. A total of 93 patients with delayed union and non-union (56 delayed unions and 37 non-unions) of the long bone were recruited from the Emergency and Outpatient Departments and treated with percutaneous autologous bone marrow injections. The clinical results of this study were rated on the basis of the criteria of union. All patients were followed for 24 months.
RESULTS
All the fractures (delayed union and non-union) were united within 12 weeks. Most of the patients had discomfort at the donor site for few days; none had problems of persistent pain. The results were excellent in 68.81% (64/93) of cases, good in 19.35% (18/93) of cases, and poor in 11.82% (11/93) of cases.
CONCLUSION
Percutaneous autologous bone marrow injection is an effective and safe method for the treatment of diaphyseal non-union and delayed union. Thus, it is concluded that with an adequate amount of autologous bone marrow injection, successful union in delayed union and non-union of fractures of long bones can be achieved.
目的
本研究旨在评估经皮注射自体骨髓治疗内固定后出现延迟愈合或不愈合骨折的效果。
方法
本前瞻性研究于2005年6月至2010年6月在骨科进行。从急诊科和门诊招募了93例长骨延迟愈合和不愈合患者（56例延迟愈合和37例不愈合），并接受经皮自体骨髓注射治疗。本研究的临床结果根据愈合标准进行评定。所有患者均随访24个月。
结果
所有骨折（延迟愈合和不愈合）均在12周内愈合。大多数患者在供区有几天不适；无人有持续性疼痛问题。68.81%（64/93）的病例结果为优，19.35%（18/93）的病例结果为良，11.82%（11/93）的病例结果为差。
结论
经皮自体骨髓注射是治疗骨干不愈合和延迟愈合的一种有效且安全的方法。因此，得出结论，通过足够量的自体骨髓注射，可以实现长骨延迟愈合和不愈合骨折的成功愈合。
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