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骨髓抽吸浓缩物治疗第五跖骨头应力性骨折:一例报告

Bone marrow aspirate concentrate for the treatment of fifth metatarsal head stress fracture: a case report.

作者信息

Nakagawa Hirotaka, Mitchell Kristen, Sussman Walter I

机构信息

Department of Orthopedics & Rehabilitation, Tufts Medical Center 800 Washington Street, Boston, MA 02111, USA.

Boston Sports & Biologics, 20 Walnut St. Suite 14, Wellesley, MA 02481, USA.

出版信息

Regen Med. 2024 Nov;19(11):529-539. doi: 10.1080/17460751.2024.2422193. Epub 2024 Nov 26.

DOI:10.1080/17460751.2024.2422193
PMID:39589901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11633430/
Abstract

Metatarsal head stress fractures pose treatment challenges with no established consensus. In this article, we introduce a percutaneous treatment involving autologous bone marrow aspirate concentrate (BMAC) injection without surgical fixation in a 21-year-old basketball player with a stress fracture of the right fifth metatarsal head. He underwent this procedure following unsuccessful 8 months of conservative treatment. Twelve weeks after the procedure, a CT scan confirmed complete healing, facilitating his return to sports. This innovative method offers a promising alternative, avoiding the associated morbidity of surgical intervention. Further research, comparing refracture rates with surgical options, is warranted to inform treatment decisions for this uncommon injury and validate the efficacy of percutaneous BMAC injection.

摘要

跖骨头应力性骨折带来了治疗挑战,目前尚无既定的共识。在本文中,我们介绍了一种经皮治疗方法,该方法是在一名21岁的右第五跖骨头应力性骨折的篮球运动员身上进行自体骨髓抽吸浓缩物(BMAC)注射,而无需手术固定。在经过8个月的保守治疗失败后,他接受了此手术。手术后12周,CT扫描证实完全愈合,使他能够重返运动。这种创新方法提供了一种有前景的替代方案,避免了手术干预相关的发病率。有必要进行进一步的研究,将再骨折率与手术选择进行比较,以为这种罕见损伤的治疗决策提供依据,并验证经皮BMAC注射的疗效。

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本文引用的文献

1
Traumatic Humeral Shaft Non-union With Ulnar Nerve Transection: An Orthobiologics Success Story.创伤性肱骨干骨不连合并尺神经横断:一个骨科生物治疗的成功案例。
Cureus. 2023 Feb 19;15(2):e35189. doi: 10.7759/cureus.35189. eCollection 2023 Feb.
2
Acute Osteochondral Fracture of the Metatarsal Head: A Report of Two Cases and Review Of Literature.跖骨头急性骨软骨骨折:两例报告及文献复习
Cureus. 2022 Oct 24;14(10):e30637. doi: 10.7759/cureus.30637. eCollection 2022 Oct.
3
Bone stress injuries.骨应力损伤
Nat Rev Dis Primers. 2022 Apr 28;8(1):26. doi: 10.1038/s41572-022-00352-y.
4
Successful Fracture Healing for Femoral Neck Nonunion with Bone Marrow Aspirate Concentrate.骨髓抽吸浓缩物治疗股骨颈骨不连的成功愈合。
R I Med J (2013). 2022 Mar 1;105(2):13-16.
5
Addition of Bone Marrow Aspirate Concentrate Resulted in High Rate of Healing and Good Functional Outcomes in the Treatment of Clavicle Fracture Nonunion: A Retrospective Case Series.添加骨髓抽吸浓缩物治疗锁骨骨折不愈合可实现高愈合率和良好功能结果:一项回顾性病例系列研究
J Clin Med. 2021 Oct 16;10(20):4749. doi: 10.3390/jcm10204749.
6
Treatment of infected tibial non-unions using a BMAC and S53P4 BAG combination for reconstruction of segmental bone defects: A clinical case series.采用 BMAC 和 S53P4 BAG 联合治疗感染性胫骨骨不连,重建节段性骨缺损:临床病例系列研究。
Injury. 2021 Jun;52 Suppl 2:S67-S71. doi: 10.1016/j.injury.2020.09.029. Epub 2020 Sep 16.
7
A Marathon Runner With Right Lateral Foot Pain.一名右足外侧疼痛的马拉松运动员。
Am J Phys Med Rehabil. 2020 Aug;99(8):766-768. doi: 10.1097/PHM.0000000000001364.
8
Characterization of Growth Factors, Cytokines, and Chemokines in Bone Marrow Concentrate and Platelet-Rich Plasma: A Prospective Analysis.骨髓浓缩物和富血小板血浆中生长因子、细胞因子和趋化因子的特性:一项前瞻性分析。
Am J Sports Med. 2019 Jul;47(9):2174-2187. doi: 10.1177/0363546519832003. Epub 2019 Apr 29.
9
Percutaneous autogenous bone marrow injection for delayed union or non-union of long bone fractures after internal fixation.经皮自体骨髓注射治疗内固定后长骨骨折的延迟愈合或不愈合
Rev Bras Ortop. 2017 Dec 29;53(6):668-673. doi: 10.1016/j.rboe.2017.09.004. eCollection 2018 Nov-Dec.
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