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一项关于23例跟骨单房性骨囊肿的研究:开放植骨同种异体骨移植与经皮注射骨粉加自体骨髓的比较

A study of 23 unicameral bone cysts of the calcaneus: open chip allogeneic bone graft versus percutaneous injection of bone powder with autogenous bone marrow.

作者信息

Park Il-Hyung, Micic Ivan Dragoljub, Jeon In-Ho

机构信息

Department of Orthopaedic Surgery, Kyungpook National University Hospital, Daegu, Republic of Korea.

出版信息

Foot Ankle Int. 2008 Feb;29(2):164-70. doi: 10.3113/FAI.2008.0164.

Abstract

BACKGROUND

The treatment of unicameral bone cyst varies from percutaneous needle biopsy, aspiration and local injection of steroid, autologous bone marrow, or demineralized bone matrix to curettage and open bone-grafting. The purpose of this study was to compare the results of open chip allogeneic bone graft versus percutaneous injection of demineralized bone powder with autogenous bone marrow in management of calcaneal cysts.

MATERIALS AND METHODS

Twenty-three calcaneal unicameral cysts in 20 patients were treated. Lyophilized irradiated chip allogeneic bone (CAB) and autogenous bone marrow were used for treatment of 13 cysts in 11 patients, and 10 cysts in 9 patients were treated with percutaneous injection of irradiated allogeneic demineralized bone powder (DBP) and autogenous bone marrow. There were 11 males and 9 female patients with mean age of 17 years.

RESULTS

The patients were followed for an average of 49.4 months. Complete healing was achieved in 9 cysts treated with chip allogeneic bone and in 5 cysts treated with powdered bone. Four cysts treated with CAB and 3 cysts treated with DBP healed with a defect. Two cysts treated with powdered bone and autogenous bone marrow were classified as persistent. No infections or pathological fractures were observed during the followup period.

CONCLUSION

Percutaneous injection of a mixture of allogeneic bone powder with autogenous bone marrow is a minimal invasive method and could be an effective alternative in the treatment of unicameral calcaneal bone cysts. The postoperative morbidity was low, the hospital stay was brief, and patient's comfort for unrestricted activity was enhanced.

摘要

背景

单纯性骨囊肿的治疗方法多种多样,从经皮穿刺活检、抽吸并局部注射类固醇、自体骨髓或脱矿骨基质,到刮除术和开放性植骨。本研究的目的是比较开放性同种异体碎骨移植与经皮注射脱矿骨粉联合自体骨髓治疗跟骨囊肿的效果。

材料与方法

对20例患者的23个跟骨单纯性囊肿进行了治疗。使用冻干辐照同种异体碎骨(CAB)和自体骨髓治疗11例患者的13个囊肿,9例患者的10个囊肿采用经皮注射辐照同种异体脱矿骨粉(DBP)和自体骨髓进行治疗。患者中男性11例,女性9例,平均年龄17岁。

结果

患者平均随访49.4个月。采用同种异体碎骨治疗的9个囊肿和采用骨粉治疗的5个囊肿实现了完全愈合。采用CAB治疗的4个囊肿和采用DBP治疗的3个囊肿愈合后有缺损。2个采用骨粉和自体骨髓治疗的囊肿被归类为持续存在。随访期间未观察到感染或病理性骨折。

结论

经皮注射同种异体骨粉与自体骨髓的混合物是一种微创方法,可能是治疗跟骨单纯性骨囊肿的有效替代方法。术后发病率低,住院时间短,患者 unrestricted activity 的舒适度提高。 (注:这里“unrestricted activity”表述可能有误,结合语境推测可能是“日常活动”之类的意思,但按要求未做修改)

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