• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

6-甲基嘌呤、6-甲基-9-β-D-呋喃核糖基嘌呤和6-羟甲基-9-β-D-呋喃核糖基嘌呤作为黄斑铆钉菇（担子菌纲）的抗病毒代谢产物。

6-Methylpurine, 6-methyl-9-beta-D-ribofuranosylpurine, and 6-hydroxymethyl-9-beta-D-ribofuranosylpurine as antiviral metabolites of Collybia maculata (Basidiomycetes).

作者信息

Leonhardt K, Anke T, Hillen-Maske E, Steglich W

出版信息

Z Naturforsch C J Biosci. 1987 Apr;42(4):420-4. doi: 10.1515/znc-1987-0415.

DOI:10.1515/znc-1987-0415
PMID:3037810
Abstract

6-Methylpurine, 6-methyl-9-beta-D-ribofuranosylpurine and 6-hydroxymethyl-9-beta-D-ribofuranosylpurine were isolated from mycelial cultures of Collybia maculata and their antifungal, cytotoxic and antiviral activities investigated. This is the first report on the natural occurrence of these compounds.

摘要

从黄斑口蘑的菌丝体培养物中分离出了6-甲基嘌呤、6-甲基-9-β-D-呋喃核糖基嘌呤和6-羟甲基-9-β-D-呋喃核糖基嘌呤，并对它们的抗真菌、细胞毒性和抗病毒活性进行了研究。这是关于这些化合物天然存在的首次报道。

相似文献

1
6-Methylpurine, 6-methyl-9-beta-D-ribofuranosylpurine, and 6-hydroxymethyl-9-beta-D-ribofuranosylpurine as antiviral metabolites of Collybia maculata (Basidiomycetes).6-甲基嘌呤、6-甲基-9-β-D-呋喃核糖基嘌呤和6-羟甲基-9-β-D-呋喃核糖基嘌呤作为黄斑铆钉菇（担子菌纲）的抗病毒代谢产物。
Z Naturforsch C J Biosci. 1987 Apr;42(4):420-4. doi: 10.1515/znc-1987-0415.
2
Synthesis and antiviral activity of certain 9-beta-D-ribofuranosylpurine-6-carboxamides.
J Med Chem. 1981 Aug;24(8):941-6. doi: 10.1021/jm00140a006.
3
Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine "acyclic" nucleoside analogues.核酸相关化合物。47. 嘧啶和嘌呤“无环”核苷类似物的合成及生物活性
J Med Chem. 1984 Nov;27(11):1486-92. doi: 10.1021/jm00377a018.
4
Adecypenol, a unique adenosine deaminase inhibitor containing homopurine and cyclopentene rings. Taxonomy, production and enzyme inhibition.
J Antibiot (Tokyo). 1986 Sep;39(9):1219-24. doi: 10.7164/antibiotics.39.1219.
5
Synthesis, antiproliferative and antiviral activity of imidazo[4,5-d]isothiazole nucleosides as 5:5 fused analogs of nebularine and 6-methylpurine ribonucleoside.咪唑并[4,5-d]异噻唑核苷作为杀稻瘟菌素和6-甲基嘌呤核糖核苷的5:5稠合类似物的合成、抗增殖及抗病毒活性
J Med Chem. 1997 Feb 28;40(5):771-84. doi: 10.1021/jm960605z.
6
Increased toxicity of 9-beta-D-arabinofuranosyladenine in the presence of an inhibitor of adenosine deaminase.在腺苷脱氨酶抑制剂存在的情况下，9-β-D-阿拉伯呋喃糖基腺嘌呤的毒性增加。
Ann N Y Acad Sci. 1977 Mar 4;284:91-102. doi: 10.1111/j.1749-6632.1977.tb21939.x.
7
Tight-binding inhibitors--IV. Inhibition of adenosine deaminases by various inhibitors.紧密结合抑制剂——IV. 各种抑制剂对腺苷脱氨酶的抑制作用
Biochem Pharmacol. 1977 Mar 1;26(5):359-67. doi: 10.1016/0006-2952(77)90192-7.
8
Synthesis of a 6-methyl-7-deaza analogue of adenosine that potently inhibits replication of polio and dengue viruses.合成一种 6-甲基-7-脱氮腺苷类似物，能有效抑制脊髓灰质炎病毒和登革热病毒的复制。
J Med Chem. 2010 Nov 25;53(22):7958-66. doi: 10.1021/jm100593s. Epub 2010 Oct 22.
9
Adecypenol, a unique adenosine deaminase inhibitor containing homopurine and cyclopentene rings.
J Antibiot (Tokyo). 1986 Feb;39(2):309-10. doi: 10.7164/antibiotics.39.309.
10
Collybial, a new antibiotic sesquiterpenoid from Collybia confluens (Basidiomycetes).
Z Naturforsch C J Biosci. 1995 Mar-Apr;50(3-4):173-180. doi: 10.1515/znc-1995-3-403.

引用本文的文献

1
Use of E. coli Purine Nucleoside Phosphorylase in the Treatment of Solid Tumors.大肠杆菌嘌呤核苷磷酸化酶在实体瘤治疗中的应用。
Curr Pharm Des. 2017 Nov 8. doi: 10.2174/1381612823666171109101851.
2
Improved synthesis of beta-D-6-methylpurine riboside and antitumor effects of the beta-D- and alpha-D-anomers.β-D-6-甲基嘌呤核糖苷的合成改进及其β-D-和α-D-端基异构体的抗肿瘤作用
Molecules. 2005 Aug 31;10(8):1015-20. doi: 10.3390/10081015.
3
The pharmacological potential of mushrooms.蘑菇的药理潜力。
Evid Based Complement Alternat Med. 2005 Sep;2(3):285-99. doi: 10.1093/ecam/neh107.