Simon Brigitte, Anke Timm, Andersb U, Neuhausb M, Hansske F
LB Biotechnologie der Universität. Paul-Ehrlich-Str. 23. D -67663 Kaiserslautern, Bundesrepublik Deutschland.
Boehringer Mannheim GmbH, Sandhofer Str. 116, D-68305 Mannheim, Bundesrepublik Deutschland.
Z Naturforsch C J Biosci. 1995 Mar-Apr;50(3-4):173-180. doi: 10.1515/znc-1995-3-403.
A new antibiotic was isolated from fermentations of an american strain of Collybia confluens. Its structure was elucidated by spectroscopic methods as 2,10,10-trimethal-4-oxo-tricyclo[7.2.0.0(2.5)]undec-6- en-carbaldehyde (with the relative stereo chemistry 1S, 2R, 5R, 9R) (1). The inhibitor, which was named collybial, is structurally related to koraiol, a sesquiterpenoid isolated from Pinus koraiensis (Khan V. A. (1979), Khim. Prir. Soedin 5, 652-658). Collybial inhibited the growth of Gram-positive bacteria at concentrations starting from 21.5 microM. The propagation of vesicular stomatitis virus (VSV) in baby hamster kidney (BHK-21) cells was inhibited by 21.5 microM collybial. Cytotoxic effects on BHK cells were observed at 5 fold higher concentrations.
