Samavarchi Tehrani Sadra, Mahmoodzadeh Hosseini Hamideh, Yousefi Tooba, Abolghasemi Maryam, Qujeq Durdi, Maniati Mahmood, Amani Jafar
Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
J Cell Biochem. 2019 Feb;120(2):1080-1105. doi: 10.1002/jcb.27617. Epub 2018 Oct 30.
DNA damage response (DDR) is a regulatory system responsible for maintaining genome integrity and stability, which can sense and transduce DNA damage signals. The severity of damage appears to determine DDRs, which can include damage repair, cell-cycle arrest, and apoptosis. Furthermore, defective components in DNA damage and repair machinery are an underlying cause for the development and progression of various types of cancers. Increasing evidence indicates that there is an association between trace elements and DDR/repair mechanisms. In fact, trace elements seem to affect mediators of DDR. Besides, it has been revealed that oxidative stress (OS) and trace elements are associated with cancer development. In this review, we discuss the role of some critical trace elements in the risk of cancer. In addition, we provide a brief introduction on DDR and OS in cancer. Finally, we will further review the interactions between some important trace elements including selenium, zinc, chromium, cadmium, and arsenic, and DDR, and OS in cancer.
DNA损伤反应（DDR）是一个负责维持基因组完整性和稳定性的调节系统，它能够感知并转导DNA损伤信号。损伤的严重程度似乎决定了DNA损伤反应，这可能包括损伤修复、细胞周期停滞和细胞凋亡。此外，DNA损伤和修复机制中的缺陷成分是各类癌症发生和发展的一个根本原因。越来越多的证据表明，微量元素与DNA损伤反应/修复机制之间存在关联。事实上，微量元素似乎会影响DNA损伤反应的介质。此外，研究还发现氧化应激（OS）和微量元素与癌症发展有关。在本综述中，我们讨论了一些关键微量元素在癌症风险中的作用。此外，我们简要介绍了癌症中的DNA损伤反应和氧化应激。最后，我们将进一步综述包括硒、锌、铬、镉和砷在内的一些重要微量元素与癌症中的DNA损伤反应及氧化应激之间的相互作用。
