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心脏磁共振成像在Fontan术后监测中的应用

The utility of cardiac magnetic resonance imaging in post-Fontan surveillance.

作者信息

Zaki Neil C, Kelleman Michael S, James Parks W, Slesnick Timothy C, McConnell Michael E, Oster Matthew E

机构信息

Emory University School of Medicine, Atlanta, Georgia.

Vanderbilt University School of Medicine, Nashville, Tennessee.

出版信息

Congenit Heart Dis. 2019 Mar;14(2):140-146. doi: 10.1111/chd.12692. Epub 2018 Oct 30.

DOI:10.1111/chd.12692
PMID:30378262
Abstract

OBJECTIVE

Gated cardiac MRI offers the most detailed and accurate noninvasive method of assessing cardiac anatomy, particularly in patients with complex congenital heart disease. The proposed benefits of using cMRI as a routine screening tool in the Fontan population include early recognition of asymptomatic, postoperative anatomic and physiologic changes. In 2011, we therefore instituted at our center a recommended practice of cMRI screening in patients with Fontan physiology at 3 and 8 years post-Fontan operation. The purpose of this study was to determine the impact of this standardized practice of cMRI screening on the clinical management of a Fontan population.

DESIGN

We retrospectively reviewed charts from our institutional Fontan database to determine which patients were eligible for cMRI under the current guidelines and who underwent imaging from November 2002 to June 2015. We reviewed the frequency of cMRI and number of changes in management based on the results. Statistical significance was determined using a chi-square test.

RESULTS

There were 141 cMRIs performed on 121 patients who met inclusion criteria. The odds of a change in management were significantly greater after clinically indicated cMRI compared to screening cMRI (OR = 3.79, 95% CI: 1.48-9.66, P = .004). There were near significant odds of change in management if the cMRI occurred <8 years after Fontan regardless of whether it was for screening or clinically indicated purposes (OR = 2.43, 95% CI: 0.97-6.08, P = .052). The most frequent change in management was referral for catheterization with pulmonary artery angioplasty.

CONCLUSIONS

There is an important role for cMRI in routine surveillance of post-Fontan patients. Screening cMRI performed less than 8 years after Fontan palliation offers increased utility compared to studies performed later. The optimal timing of such imaging after Fontan palliation remains unclear.

摘要

目的

门控心脏磁共振成像(MRI)提供了评估心脏解剖结构最详细、最准确的非侵入性方法,尤其是对于患有复杂先天性心脏病的患者。将心脏磁共振成像(cMRI)用作Fontan人群常规筛查工具的潜在益处包括早期识别无症状的术后解剖和生理变化。因此,在2011年,我们中心制定了一项推荐做法,即在Fontan手术3年和8年后对具有Fontan生理特征的患者进行cMRI筛查。本研究的目的是确定这种标准化的cMRI筛查做法对Fontan人群临床管理的影响。

设计

我们回顾性查阅了机构Fontan数据库中的病历,以确定哪些患者符合当前指南下的cMRI检查条件,以及哪些患者在2002年11月至2015年6月期间接受了成像检查。我们根据结果审查了cMRI的频率和管理变化的数量。使用卡方检验确定统计学意义。

结果

对121名符合纳入标准的患者进行了141次cMRI检查。与筛查性cMRI相比,临床指征性cMRI后管理发生变化的几率显著更高(比值比[OR]=3.79,95%置信区间[CI]:1.48-9.66,P=0.004)。无论cMRI是用于筛查还是临床指征目的,如果在Fontan手术后<8年进行,管理发生变化的几率接近显著(OR=2.43,95%CI:0.97-6.08,P=0.052)。最常见的管理变化是转诊进行导管插入术及肺动脉血管成形术。

结论

cMRI在Fontan术后患者的常规监测中具有重要作用。与后期进行的研究相比,在Fontan姑息治疗后不到8年进行的筛查性cMRI具有更高的效用。Fontan姑息治疗后这种成像的最佳时机仍不清楚。

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