Sek B, Sebastjanska A, Nowak J Z
Agents Actions. 1987 Apr;20(3-4):244-7. doi: 10.1007/BF02074681.
Histamine (HI) potently stimulated, through H2-receptors, cAMP accumulation in slices of the rabbit cerebral cortex (EC50: 15 microM; maximum stimulation: 300-450% of the basal level). Combination of L-noradrenaline or L-adrenaline and adenosine with HI showed synergistic and additive effects, respectively. Carbachol, arecoline and pilocarpine had no effect, while oxotremorine and tremorine increased and decreased the HI response when used at low or high concentrations, respectively.
组胺（HI）通过H2受体有力地刺激兔大脑皮层切片中cAMP的积累（半数有效浓度：15微摩尔；最大刺激：基础水平的300 - 450%）。L - 去甲肾上腺素或L - 肾上腺素与腺苷和HI联合使用时，分别显示出协同作用和相加作用。卡巴胆碱、槟榔碱和毛果芸香碱无作用，而氧化震颤素和震颤素分别在低浓度或高浓度使用时，增强和减弱了HI反应。
