Sek B, Sebastjanska A, Nowak J Z
Department of Biogenic Amines, Polish Academy of Sciences, Lódź.
Agents Actions. 1988 Apr;23(3-4):237-40. doi: 10.1007/BF02142551.
Histamine (HI) potently stimulated, through H2-receptors, cAMP accumulation in rabbit cerebral cortical slices but not in retinal pieces. The action of HI in the cerebral cortex was not significantly affected by dopamine, serotonin, melatonin and GABA-ergic drugs. Forskolin markedly stimulated cAMP accumulation both in the cerebral cortex and retina. There was a synergistic interaction between HI and forskolin in the cerebral cortex, whereas in the retina HI decreased the forskolin-activated cAMP accumulation.
组胺（HI）通过H2受体强烈刺激兔大脑皮层切片中的环磷酸腺苷（cAMP）积累，但对视网膜切片无此作用。多巴胺、5-羟色胺、褪黑素和γ-氨基丁酸（GABA）能药物对HI在大脑皮层的作用无显著影响。福斯高林显著刺激大脑皮层和视网膜中的cAMP积累。在大脑皮层中，HI与福斯高林之间存在协同相互作用，而在视网膜中，HI降低了福斯高林激活的cAMP积累。
