Schimke R N, Collins D, Cross D
Am J Med Genet. 1987 May;27(1):195-202. doi: 10.1002/ajmg.1320270121.
We report on a family ascertained because of sibs affected with nasopharyngeal carcinoma. Other relatives had aplastic anemia or other malignancies and most were born of consanguineous parents. Epstein-Barr virus has been strongly implicated in the pathogenesis of nasopharyngeal carcinoma. It has also been suggested as a cause of aplastic anemia and other neoplasms. We postulate that this extensive German-Mennonite family has a heritable defect in the immune response to Epstein-Barr virus making its members at excessive risk for a number of different malignancies. This immunologic predisposition may be HLA associated and appears to be inherited as an autosomal recessive trait.
我们报告了一个因患鼻咽癌的同胞而被确定的家族。其他亲属患有再生障碍性贫血或其他恶性肿瘤，且大多数是近亲结婚父母所生。爱泼斯坦-巴尔病毒与鼻咽癌的发病机制密切相关。它也被认为是再生障碍性贫血和其他肿瘤的病因。我们推测，这个庞大的德裔门诺派家族在对爱泼斯坦-巴尔病毒的免疫反应中存在遗传性缺陷，使其成员患多种不同恶性肿瘤的风险过高。这种免疫易感性可能与 HLA 相关，并且似乎作为常染色体隐性性状遗传。
