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使用聚合物纳米盘生成的阿尔茨海默病淀粉样-β中间产物。

Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs.

机构信息

Biophysics and Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA.

出版信息

Chem Commun (Camb). 2018 Nov 13;54(91):12883-12886. doi: 10.1039/c8cc07921h.

DOI:10.1039/c8cc07921h
PMID:30379172
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6247814/
Abstract

Polymethacrylate-copolymer (PMA) encased lipid-nanodiscs (∼10 nm) and macro-nanodiscs (>15 nm) are used to study Aβ1-40 aggregation. We demonstrate that PMA-nanodiscs form a ternary association with Aβ and regulate its aggregation kinetics by trapping intermediates. Results demonstrating the reduced neurotoxicity of nanodisc-bound Aβ oligomers are also reported.

摘要

多聚甲基丙烯酸酯共聚物 (PMA) 包裹的脂质纳米盘（~10nm）和大纳米盘（>15nm）被用于研究 Aβ1-40 聚集。我们证明 PMA-纳米盘与 Aβ 形成三元复合物，并通过捕获中间体来调节其聚集动力学。还报告了纳米盘结合的 Aβ 寡聚物的神经毒性降低的结果。

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[1]
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本文引用的文献

[1]
Nanodisc-Forming Scaffold Protein Promoted Retardation of Amyloid-Beta Aggregation.

J Mol Biol. 2018-8-28

[2]
Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes.

Nat Chem. 2018-5-7

[3]
Spontaneous Lipid Nanodisc Fomation by Amphiphilic Polymethacrylate Copolymers.

J Am Chem Soc. 2017-12-5

[4]
High-Affinity Binding of Monomeric but Not Oligomeric Amyloid-β to Ganglioside GM1 Containing Nanodiscs.

Biochemistry. 2016-12-6

[5]
Biomimetic ApoE-Reconstituted High Density Lipoprotein Nanocarrier for Blood-Brain Barrier Penetration and Amyloid Beta-Targeting Drug Delivery.

Mol Pharm. 2016-11-7

[6]
GM1 Ganglioside Inhibits β-Amyloid Oligomerization Induced by Sphingomyelin.

Angew Chem Int Ed Engl. 2016-6-13

[7]
Alzheimer's disease.

Nat Rev Dis Primers. 2015-10-15

[8]
Amyloid-β adopts a conserved, partially folded structure upon binding to zwitterionic lipid bilayers prior to amyloid formation.

Chem Commun (Camb). 2016-1-18

[9]
Accurate secondary structure prediction and fold recognition for circular dichroism spectroscopy.

Proc Natl Acad Sci U S A. 2015-6-16

[10]
Small liposomes accelerate the fibrillation of amyloid β (1-40).

J Biol Chem. 2015-1-9

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