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谁做出了诊断并开了什么药?利用医疗服务提供者的详细信息为观察性研究提供依据。

Who diagnosed and prescribed what? Using provider details to inform observational research.

作者信息

Bushnell Greta A, Stürmer Til, Mack Christina, Pate Virginia, Miller Matthew

机构信息

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Real-World & Analytic Solutions, IQVIA, Durham, North Carolina, USA.

出版信息

Pharmacoepidemiol Drug Saf. 2018 Dec;27(12):1422-1426. doi: 10.1002/pds.4685. Epub 2018 Oct 31.

Abstract

PURPOSE

To describe how often patients with depression initiating antidepressants receive their depression diagnosis and prescriptions from the same provider and, when simultaneously initiating benzodiazepines, how often both prescriptions come from the same provider.

METHODS

Using a US healthcare claims database, we created a cohort of adults (18-64 years) with a depression diagnosis who initiated antidepressants. We examined concordance by provider specialty and provider identifier between (a) the first antidepressant prescription fill and most proximal depression diagnosis, and (b) the initial antidepressant and benzodiazepine prescription fills among simultaneous benzodiazepine and antidepressant initiators.

RESULTS

Among 245 166 antidepressant initiators with a recent depression diagnosis (female = 67%; median age = 39), the specialty of the provider assigning the depression diagnosis matched the antidepressant prescriber's specialty in 94% of cases with known provider details (provider identifier concordance = 93%). Concordance was higher for adults diagnosed by a general practitioner (98%) or psychiatrist (92%) than for those diagnosed by a psychologist (74%). In simultaneous new users of antidepressants and benzodiazepines (n = 19 371), both prescriptions were issued by the same provider specialty and provider identifier 94% and 93% of the time, respectively.

CONCLUSIONS

The vast majority of patients who received antidepressant prescriptions and depression diagnoses appear to have received both diagnosis and antidepressants from the same provider, suggesting that when antidepressants are issued around the time a patient is diagnosed with depression, the antidepressant was likely prescribed for depression. In addition, the great majority of patients who simultaneously initiate benzodiazepines appear to do so under the direction of one provider.

摘要

目的

描述开始使用抗抑郁药的抑郁症患者从同一医疗服务提供者处获得抑郁症诊断和处方的频率,以及在同时开始使用苯二氮䓬类药物时,两种处方均来自同一医疗服务提供者的频率。

方法

利用美国医疗保健理赔数据库,我们创建了一个开始使用抗抑郁药且被诊断为抑郁症的成年人队列(18 - 64岁)。我们按医疗服务提供者的专业和标识,检查了(a)首次抗抑郁药处方配药与最近一次抑郁症诊断之间的一致性,以及(b)同时开始使用苯二氮䓬类药物和抗抑郁药的患者中,初始抗抑郁药和苯二氮䓬类药物处方配药之间的一致性。

结果

在245166名近期被诊断为抑郁症的抗抑郁药使用者中(女性占67%;中位年龄39岁),在已知医疗服务提供者详细信息的病例中,94%的情况下,做出抑郁症诊断的医疗服务提供者专业与抗抑郁药开处方者的专业相匹配(医疗服务提供者标识一致性为93%)。由全科医生(98%)或精神科医生(92%)诊断的成年人,其一致性高于由心理学家诊断的成年人(74%)。在同时开始使用抗抑郁药和苯二氮䓬类药物的新使用者中(n = 19371),两种处方分别有94%和93%的时间是由同一医疗服务提供者专业和标识开具的。

结论

绝大多数接受抗抑郁药处方和抑郁症诊断的患者似乎是从同一医疗服务提供者处获得诊断和抗抑郁药的,这表明当患者被诊断为抑郁症时开具抗抑郁药,该抗抑郁药很可能是用于治疗抑郁症的。此外,绝大多数同时开始使用苯二氮䓬类药物的患者似乎是在同一医疗服务提供者的指导下进行的。

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