Facultad de Medicina, Universidad Autónoma de Querétaro, Clavel No 200, Col. Prados de la Capilla, 76176 Querétaro, Mexico.
División de Estudios de Posgrado, C.A. Ingeniería de Biosistemas. Facultad de Ingeniería. Universidad Autónoma de Querétaro, C. U. Cerro de las Campanas, S/N, 76010 Querétaro, Mexico.
Molecules. 2018 Oct 30;23(11):2812. doi: 10.3390/molecules23112812.
In Mexico one in 14 deaths are caused by diabetes mellitus (DM) or by the macro and microvascular disorders derived from it. A continuous hyperglycemic state is characteristic of DM, resulting from a sustained state of insulin resistance and/or a dysfunction of β-pancreatic cells. is a little studied species showing a significant antioxidant activity that can be used as treatment of this disease or preventive against the complications. The objective of this study was to explore the effect of oral administration of methanol extract on physiological parameters of streptozotocin-induced diabetic rats. The results indicated a significant reduction in blood glucose levels, an increase in serum insulin concentration, a decrease in lipid levels and an improvement in the parameters of kidney damage by applying a concentration of 100 mg/Kg B.W. However, glucose uptake activity was not observed in the adipocyte assay. Moreover, the extract of displayed potential for the complementary treatment of diabetes and its complications likely due to the presence of bioactive compounds such as protocatechuic acid. This study demonstrated that methanol extract of has an antidiabetic effect by reducing the levels of glucose, insulin and improved physiological parameters, hypolipidemic effect, oxidative stress and renal damage in diabetic rats.
在墨西哥，每 14 例死亡中就有一例是由糖尿病（DM）或由此引发的大血管和微血管病变引起的。高血糖状态是 DM 的特征，这是由胰岛素抵抗和/或β-胰腺细胞功能障碍的持续状态引起的。是一种研究较少的物种，具有显著的抗氧化活性，可用于治疗这种疾病或预防并发症。本研究旨在探讨口服甲醇提取物对链脲佐菌素诱导的糖尿病大鼠生理参数的影响。结果表明，应用 100mg/KgB.W.浓度时，血糖水平显著降低，血清胰岛素浓度升高，脂类水平降低，肾脏损伤参数改善。然而，在脂肪细胞测定中没有观察到葡萄糖摄取活性。此外，由于存在原儿茶酸等生物活性化合物，提取物可能具有治疗糖尿病及其并发症的潜力。本研究表明，甲醇提取物具有降低血糖、胰岛素水平和改善糖尿病大鼠生理参数、降血脂作用、氧化应激和肾损伤的抗糖尿病作用。
